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Composites of amorphous calcium phosphate and poly(hydroxybutyrate) and poly(hydroxybutyrate-co-hydroxyvalerate) for bone substitution: assessment of the biocompatibility

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Abstract

Composites of amorphous carbonated apatite and poly-(R)-3-hydroxybutyrate (PHB) and poly-(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate (PHBHV), respectively, were studied by pH monitoring upon immersion in water and by long-term osteoblast culture. For comparison, α-tricalcium phosphate (α-TCP), one glass ceramic (GB 9N), and one bioglass (Mg 5) were subjected to the same experiments. Excellent cell proliferation was found on the composite of calcium phosphate with PHB and on the reference materials (α-TCP, glass ceramic, bioglass). In contrast, cell death was observed repeatedly on the composite with PHBHV. A composite of amorphous calcium phosphate and PHB appears to be well suited as slowly biodegradable bone substitution material.

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Acknowledgments

We thank C. Müldner, R. Walter, D. Keyser, and D. Tadic for experimental assistance. Financial assistance by the Deutsche Forschungsgemeinschaft (Graduiertenkolleg 476 to J.M.R. and M.E.; fellowships to A.F.S., K.S. and M.S.) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Trauma, Hand and Reconstructive Surgery, Hamburg University, School of Medicine, Martinistrasse 52, D-20246, Hamburg, Germany

    Wolfgang Linhart, Wolfgang Lehmann, Arndt F. Schilling, Michael Amling & Johannes Maria Rueger

  2. Inorganic Chemistry, University of Duisburg–Essen, D-45117, Essen, Germany

    Michael Siedler, Fabian Peters, Karsten Schwarz & Matthias Epple

Authors
  1. Wolfgang Linhart
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  2. Wolfgang Lehmann
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  3. Michael Siedler
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  4. Fabian Peters
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  5. Arndt F. Schilling
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  6. Karsten Schwarz
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  7. Michael Amling
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  8. Johannes Maria Rueger
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  9. Matthias Epple
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Corresponding author

Correspondence to Matthias Epple.

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No benefit of any kind will be received either directly or indirectly by the authors.

W. Linhart and W. Lehmann contribute equally and therefore share first authorship

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Linhart, W., Lehmann, W., Siedler, M. et al. Composites of amorphous calcium phosphate and poly(hydroxybutyrate) and poly(hydroxybutyrate-co-hydroxyvalerate) for bone substitution: assessment of the biocompatibility. J Mater Sci 41, 4806–4813 (2006). https://doi.org/10.1007/s10853-006-0023-x

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  • DOI: https://doi.org/10.1007/s10853-006-0023-x

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