Fabrication and characterisation studies of cyclodextrin-based nanosponges for sulfamethoxazole delivery


β-Cyclodextrin based nanosponges have been synthesized in three molar ratios, and characterized by phase solubility studies, Fourier-transform infrared spectroscopy, matrix-assisted laser desorption/ionization time of flight mass spectrometry, and scanning electron microscopy. Following characterization studies, a model anti-bacterial agent, sulfamethoxazole, has been loaded within the nanosponges, and in vitro drug release studies were carried out. According to results, nanosponges below  ~ 100 nm diameter were obtained with a characteristic sponge-like morphology. Phase solubility studies demonstrated that β-cyclodextrin nanosponges improve solubility of the drug up to 30-fold. These results suggest that nanosponges could improve the bioavailability of drugs by conducing them to reach desired plasma concentrations for therapeutic effect.

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This project has been supported by Marmara University Scientific Research Projects Coordination Unit under grant number SAG-C-YLP-081117-0612. We would like to thank to Biofarma Pharmaceuticals (Turkey) for providing Sulfamethoxazole as a gift. The authors appreciate Dr. Jürgen H. Gross at Institute of Organic Chemistry of the University of Heidelberg (Germany) for MALDI–TOF MS analyses. We thank to Fatih Serdar SAYIN from Marmara University, Faculty of Technology, Department of Electrical-Electronics Engineering for SEM studies.

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Yaşayan, G., Şatıroğlu Sert, B., Tatar, E. et al. Fabrication and characterisation studies of cyclodextrin-based nanosponges for sulfamethoxazole delivery. J Incl Phenom Macrocycl Chem 97, 175–186 (2020). https://doi.org/10.1007/s10847-020-01003-z

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  • β-Cyclodextrin
  • Nanosponge
  • Cross-linking
  • 1,1′-Carbonyldiimidazole
  • Sulfamethoxazole
  • Drug release