Abstract
The inclusion constants of tetraalkylammonium salts (ASs) with cucurbit[7]uril (CB[7]) were determined at high-pressures using methylene blue as a chemical indicator. CB[7] formed 1:1 inclusion complexes with ASs. We found a characteristic dependence of the alkyl chain substituents in ASs on the inclusion equilibrium, which was responsible for the formation of clathrate hydrates of the AS in bulk. Furthermore, we examined the effects of external high pressures on the CB[7] inclusion complexations of ASs having different alkyl chain lengths. Pressure dependence experiments allowed us to calculate the reaction volume (ΔV) upon inclusion; i.e., the volume change (ΔVdesolv) accompanying desolvation around the guest molecules and the volume change (ΔVrepel) caused by the water molecules repelled from the CB[7] cavity. The volumetric study for the inclusion of ASs with CB[7] showed that in the tetraheptylammonium ion, one arm (alkyl chain) was encapsulated in the CB[7] cavity, while in other ASs, two arms were located in the cavity. NMR measurements of the complexes and pressure-dependent studies provided unique information on the structures of the inclusion complexes of ASs with CB[7].
Similar content being viewed by others
References
Lagona, J., Mukhopadhyay, P., Chakrabarti, S., Isaacs, L.: The cucurbit[n]uril family. Angew. Chem. Int. Ed. 44, 4844–4870 (2005)
Hettiaracchchi, D.S.N., Macartney, D.H.: Cucurbit[7]uril host-guest complexes with cationic bis(4,5-dihydro-1H-imidazol-2-yl) guests in aqueous solution. Can. J. Chem. 84, 905–914 (2006)
Marquez, C., Hudgins, R.R., Nau, W.M.: Mechanism of host-guest complexation by cucurbituril. J. Am. Chem. Soc. 126, 5806–5816 (2004)
Lee, J.W., Samal, S., Selvapalam, N., Kim, H.–J., Kim, K.: Cucurbituril homologues and derivatives: new opportunities in supramolecular chemistry. Acc. Chem. Res. 36, 621–630 (2003)
St-Jacques, A.D., Wyman, I.W., Macartney, D.H.: Encapsulation of charge-diffuse peralkylated onium cations in the cavity of cucurbit[7]uril. Chem. Commun. (2008). https://doi.org/10.1039/B811823J
Sueishi, Y., Tobisako, H., Kotake, Y.: Distinctive pressure effects on the association equilibrium in cyclodextrin group-inclusion complex as studied with electron paramagnetic resonance. J. Phys. Chem. B 108, 12623–12627 (2004)
Sueishi, Y., Honda, Y., Fujitani, S., Inazumi, N., Hanaya, T.: Investigation of inclusion complexation of imidazolium and pyrrolidinium chlorides with water-soluble p-sulfonatocalix[6]arene: characteristic effects of external pressure, temperature, and substituents. J. Incl. Phenom. Macrocycl. Chem. 86, 255–261 (2016)
Marquez, C., Huang, F., Nau, W.M.: Cucurbiturils: molecular nanocapsules for time-resolved fluorescence-based assays. IEEE Trans. Nanobiosci. 3, 39–45 (2004)
Sueishi, Y., Itami, S.: Investigation of the pressure effects on inclusion equilibria of substituted phenols with β- and γ-cyclodextrins. Z. Phys. Chem. 217, 677–688 (2003)
Job, P.: Formation and stability of inorganic complexes in solution. Ann. Chim. 9, 113–203 (1928)
Sueishi, Y., Asano, K., Yamaoka, M., Yamamoto, S.: Characterization of water-soluble cucurbit[7]uril in alcohol-water mixtures by high-pressure studies on the inclusion complexation with new methylene blue. Z. Phys. Chem. 222, 153–161 (2008)
Miskolczy, Z., Biczok, L., Megyesi, M., Jablonkai, I.: Inclusion complex formation of ionic liquids and other cationic organic compounds with cucurbit[7]uril studied by 4′,6-diamidino-2-phenylindole fluorescence probe. J. Phys. Chem. B 113, 1645–1651 (2009)
Nakayama, H., Watanabe, K.: Hydrates of organic compounds. II. The effect of alkyl groups on the formation of quaternary ammonium fluoride hydrates. Bull. Chem. Soc. Jpn. 49, 1254–1256 (1976)
Leffler, J.E.: The interpretation of enthalpy and entropy data. J. Org. Chem. 31, 533–537 (1966)
Castronuovo, G., Niccoli, M.: Solvent effects on the complexation of 1-alkanols by parent and modified cyclodextrins. Calorimetric studies at 298 K. J. Therm. Anal. Calorim. 103, 641–646 (2011)
Drljaca, A., Hubbard, C.D., van Eldik, R., Asano, T., Basilevsky, M.V., le Noble, W.J.: Activation and reaction volumes in solution. 3. Chem. Rev. 98, 2167–2289 (1998)
Lindner, K., Saenger, W.: β-Cyclodextrin dodecahydrate: crowding of water molecules within a hydrophobic cavity. Angew. Chem. Int. Engl. 17, 694 (1978)
Biedemann, F., Uzunova, V.D., Scherman, O.A., Nau, W.M.: Release of high-energy water as an essential driving force for the high-affinity binding of cucurbit[n]urils. J. Am. Chem. Soc. 134, 15318–15323 (2012)
Author information
Authors and Affiliations
Corresponding author
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Matsumoto, Y., Inazumi, N., Hanaya, T. et al. Characterization of inclusion complexation of various tetraalkylammonium chlorides with cucurbit[7]uril by external high-pressure studies. J Incl Phenom Macrocycl Chem 92, 205–210 (2018). https://doi.org/10.1007/s10847-018-0832-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10847-018-0832-y