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Characterization of the inclusion complex of the essential oil of Lantana camara L. and β-cyclodextrin by vibrational spectroscopy, GC–MS, and X-ray diffraction

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Abstract

The genus Lantana is widely used in folk medicine because its essential oil has antibacterial, antifungal and repellent activity. However, its thermal instability and low solubility in water reduce its technological application. In this work, an inclusion complex was prepared consisting of the essential oil of Latana camara L. (LCEO) and β-cyclodextrin (β-CD). The complex was characterizated by vibrational spectroscopy (Raman and FTIR spectroscopy), differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The optimization of the ratio of the LCEO and β-CD in the inclusion complex was determined by gas chromatography coupled to mass spectrometry (GC–MS); it was inferred that the ratio of guest–host = 6:94 (m:m) was the optimal ratio. Shifts in some peak positions of the vibrations modes in Raman spectra of L. camara and β-CD provided clearer and better evidence of inclusion complex formation than infrared spectroscopy did. Results of DSC and XRD characterization of inclusion complex are in good agreement with Raman results.

Graphical Abstract

Formation of the inclusion complex between β-CD and LCEO as well as its characterization by different analytical techniques such as infrared spectroscopy and Raman spectroscopy, DSC, XRD and GC–MS.

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Acknowledgements

The authors would like to acknowledge the UFPI and CNPq for financial support and FISMAT and LAPETRO for the analyzes.

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  1. Programa de Pós-Graduação em Química, Universidade Federal do Piauí (UFPI), Campus Ministro Petrônio Portella, CEP: 64049-550, Teresina, PI, Brazil

    Márcio dos S. Rocha & Sidney G. de Lima

  2. Programa de Pós-Graduação Ciência e Engenharia de Materiais, Universidade Federal do Piauí (UFPI), Campus Ministro Petrônio Portella, CEP: 64049-550, Teresina, PI, Brazil

    Bartolomeu C. Viana & Francisco E. P. Santos

  3. Graduate Program in Molecular Bioprospection, Laboratory of Natural Products Research, URCA, Crato, CE, Brazil

    José Galberto Martins Costa

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  1. Márcio dos S. Rocha
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  3. Bartolomeu C. Viana
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Rocha, M.d.S., de Lima, S.G., Viana, B.C. et al. Characterization of the inclusion complex of the essential oil of Lantana camara L. and β-cyclodextrin by vibrational spectroscopy, GC–MS, and X-ray diffraction. J Incl Phenom Macrocycl Chem 91, 95–104 (2018). https://doi.org/10.1007/s10847-018-0799-8

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