Study on the inclusion behaviour and solid inclusion complex of lomustine with cyclodextrins
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The water soluble solid inclusion complex of three native or modified cyclodextrins (CDs) including β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (Hp-β-CD) and 2,6-di-o-methyl-β-cyclodextrin (DIME-β-CD) and Lomustine (CCNU) were presented with the orthogonal experiment investigation of the reaction conditions. The inclusion behaviors were comparatively investigated by nuclear magnetic resonance in combination with infrared spectroscopy, thermogravimetric analysis, X-ray diffractometry and scanning electron microphotographs. The experimental results jointly demonstrated that the entrance of CCNU into the cavity of the CDs by intermolecular forces as well as hydrophobic forces and resulting in the significantly improvement of the thermostability of CCNU.
KeywordsCyclodextrin Lomustine Inclusion NMR
We thank the National Natural Science Foundation of China (NSFC 21572177; 21272184; 21103137 and J1210057), the Shaanxi Provincial Natural Science Fund Project (No. 2015JZ003), the Xi’an City Science and Technology Project (Nos. CXY1511(3)), the Northwest University Science Foundation for Postgraduate Students (Nos. YZZ14052), the Chinese National Innovation Experiment Program for University Students (No. 201510697004) and Scientific Research Cultivating Fund of Xi’an University of Science and Technology (No. 201619) for financial support.
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