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Photostability of water-soluble inclusion complexes of UV-filters and curcumin with gamma-cyclodextrin polymer

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Abstract

The water-soluble inclusion complexes of curcumin, 2-ethylhexyl-4-methoxycinnamate (EHMC) and 4-tert-butyl-4′-methoxydibenzoylmethane (DBM) with gamma-cyclodextrin polymer (pyCD) were successfully prepared and characterized by 1H-NMR, IR and UV–Vis spectroscopies. The water-solubility of EHMC–pyCD, DBM–pyCD and curcumin–pyCD was dramatically increased because of the water-soluble pyCD. The mole ratio of gamma-CD in pyCD to EHMC, DBM and curcumin were carried out as 1:1. The photostability of all inclusion complexes was investigated in water and ethylene glycol and compared with free active ingredients. It was found that the photostability of EHMC–pyCD was greatly enhanced whereas those of DBM–pyCD and curcumin–pyCD in water were decreased due to the acceleration of the photodegradation reaction inside the gamma-CD cavity. These results were able to be used as a solubilizer for cosmetic and also pharmaceutical applications.

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Acknowledgments

The authors acknowledged the financial support from Kasetsart University Research and Development Institute (KURDI-10.57) and the Faculty of Science, Kasetsart University (URMF).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Kasetsart University, 50 Ngamwongwan Rd, Chatuchak, Bangkok, 10900, Thailand

    Thitinun Karpkird, Raweewan Khunsakorn, Chaiwat Noptheeranuphap & Junya Jettanasen

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  1. Thitinun Karpkird
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  2. Raweewan Khunsakorn
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  3. Chaiwat Noptheeranuphap
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  4. Junya Jettanasen
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Correspondence to Thitinun Karpkird.

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Karpkird, T., Khunsakorn, R., Noptheeranuphap, C. et al. Photostability of water-soluble inclusion complexes of UV-filters and curcumin with gamma-cyclodextrin polymer. J Incl Phenom Macrocycl Chem 84, 121–128 (2016). https://doi.org/10.1007/s10847-015-0589-5

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  • DOI: https://doi.org/10.1007/s10847-015-0589-5

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