Naphthyridine amide–urea conjugate: a case toward selective fluorometric sensing of N-acetyl proline carboxylate
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A simple neutral naphthyridine-based chemosensor 1, which selectively recognizes the tetrabutylammonium salt of N-acetyl-l-proline over the other N-acetyl-l-amino acid salts studied in CHCl3 containing 0.1% DMSO, has been designed and synthesized. Moreover, the complexation-induced change in emission characteristics of 1 distinguishes the amino acid salts examined from their conjugate acids. Interaction studies were performed by UV–vis, fluorescence and NMR spectroscopic methods.
KeywordsNaphthyridine Urea binding site Proline salt recognition Fluorometric distinction DFT calculation
We thank CSIR, New Delhi, India for financial support. T.S thanks CSIR, New Delhi, India for providing fellowship. We also thank the reviewer for constructive criticism.
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