Abstract
Due to its broad-action spectra nystatin has been used for years for mucocutaneous candidosis, still its clinical use has been limited due to the lack of absorption by the oral route, and systemic side-effects and toxicity. In order to overcome low water solubility and high toxicity new conjugates nystatin–polyethylene oxide were synthesized and characterized from physico-chemical, as also from the controlled release pattern and antifungal efficacy point of view. To the knowledge of the authors this structure has not been reported previously in the literature and indicate an interesting release pattern as well as increased biological activity.
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Acknowledgments
This research was financially supported by European Social Fund –„Cristofor I. Simionescu” Postdoctoral Fellowship Programme (IDPOSDRU/89/1.5/S/55216), Human Resources Development 2007–2013. The authors will like to express their gratitude to Dr. Valeria Harabagiu, Dr. Xenia Patras and Dr. Aurica Farcas for their advice and guidance in understanding the complexity of the described phenomena.
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Spulber, M., Fifere, A., Anamaria, DA. et al. Nystatin–polyethylene oxide conjugates with enhanced solubility in water. J Incl Phenom Macrocycl Chem 71, 87–93 (2011). https://doi.org/10.1007/s10847-010-9905-2
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DOI: https://doi.org/10.1007/s10847-010-9905-2