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A comparative study of complexation methods for cefdinir-hydroxypropyl-β-cyclodextrin system

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Abstract

The aim of this study was to investigate the effect of hydroxypropyl-β-cyclodextrin (HPβCD) on the solubility and dissolution rate of Cefdinir (CEF). The methods that were employed to prepare CEF–HPβCD complexes were Kneading (KN), Co-evaporation (CE), Spray drying (SD) and a novel approach of Microwave irradiation (MWI). The formation of inclusion complexes with HPβCD in the solid state, were characterized by Differential Scanning Calorimetry (DSC), Fourier Transformation Infrared spectroscopy (FTIR), Proton Nuclear Magnetic Resonance Spectroscopy (NMR), X Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) studies, and comparative studies on the in vitro dissolution of CEF were carried out. Phase solubility profile with HPβCD was classified as AL type, indicating the formation of 1:1 stoichiometric inclusion complexes. Characterization of binary systems by DSC, FTIR, NMR, XRD and SEM indicated that SD and MWI method resulted in formation of true complexes. Binary systems showed significant increase in dissolution rate as compared to plain drug. Amongst the various binary systems, MWI products were prepared in least time with better yield and highest dissolution rate.

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Acknowledgment

The authors would like to place on record their sincere gratitude to Alkem Research Lab. Ltd (India) for kindly gifting Cefdinir and Wacker Fine Chemical Corporation (Germany) for generously providing HPβCD.

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Authors and Affiliations

  1. Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Sector-8, Navi Mumbai, 400614, India

    Vij Mohit, Garse Harshal, Dand Neha, Kadam Vilasrao & Hirlekar Rajashree

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  1. Vij Mohit
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  2. Garse Harshal
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  3. Dand Neha
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Correspondence to Hirlekar Rajashree.

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Mohit, V., Harshal, G., Neha, D. et al. A comparative study of complexation methods for cefdinir-hydroxypropyl-β-cyclodextrin system. J Incl Phenom Macrocycl Chem 71, 57–66 (2011). https://doi.org/10.1007/s10847-010-9901-6

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