Improved aqueous Cannizzaro reaction in presence of cyclodextrin
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An aqueous hydroxypropyl-β-cyclodextrin solution has been used to increase the conversion of 4-biphenylcarboxaldehyde into the corresponding alcoholic and carboxylic substrates, by means of a Cannizzaro reaction. The observed enhancement has been ascribed to a partial solubilization of 4-biphenylcarboxaldehyde. In addition, as the main part of the organic substrates still remains insoluble, synthesized products are easily recovered by filtration. As a consequence, the basic cyclodextrin solution might also be reused for a new synthetic cycle, without significant loss of conversion. Aqueous solid–liquid biphasic reaction in presence of cyclodextrins thus seems to be a promising tool in the green chemistry field.
KeywordsCyclodextrin Phase transfer agent Solid–liquid reaction Cannizzaro Reaction
Authors wish to thank IRENI for financial support.
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