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The effect of β-cyclodextrin on the solubility and dissolution rate of meloxicam and investigation of the driving force for complexation using molecular modeling

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Abstract

The aim of this study was to investigate the effect of β-cyclodextrin (β-CD) on the solubility and dissolution rate of meloxicam. The methods that were employed to prepare meloxicam–β-cyclodextrin complexes were physical mixture, kneaded dispersion, and spray drying. Spray drying method was found to be the best to form a true inclusion complex. Complexes were characterized by thermal analysis, X-ray diffractometry (XRD), and Fourier transform infrared (FT-IR) spectroscopy. The apparent stability constant of the complex, K c, calculated from the slope and intercept of the AL solubility diagram was found to be 429.73, 259.96, 183.31, and 36.50 L mol−1 at pH 2, 3, 6.5, and 10.3, respectively. The dissolution rate of meloxicam from the complexes was higher than from meloxicam alone. Molecular modeling was also used to investigate the interaction between meloxicam and β-CD. The dominant driving force for the complexation was evidently Van der Waals force with very little electrostatic contribution.

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  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan

    Aiman A. Obaidat, Rasha A. Khanfar & Mohammad N. Khawam

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  1. Aiman A. Obaidat
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  2. Rasha A. Khanfar
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  3. Mohammad N. Khawam
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Correspondence to Aiman A. Obaidat.

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Obaidat, A.A., Khanfar, R.A. & Khawam, M.N. The effect of β-cyclodextrin on the solubility and dissolution rate of meloxicam and investigation of the driving force for complexation using molecular modeling. J Incl Phenom Macrocycl Chem 63, 273–279 (2009). https://doi.org/10.1007/s10847-008-9517-2

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  • DOI: https://doi.org/10.1007/s10847-008-9517-2

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