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NMR spectroscopic study of the inclusion complex of desloratadine with β-cyclodextrin in solution

  • Syed Mashhood Ali
  • Santosh Kumar Upadhyay
  • Arti Maheshwari
Original Article

Abstract

Desloratadine (DES) is an antihistamine used in the treatment of allergies and chronic urticaria. 1H NMR spectroscopic study of varying ratios of DES and β-Cyclodextrin (β-CD) in D2O suggests the formation of a 1:1 inclusion complex formed by the penetration of Cl-substituted aromatic ring into the β-CD cavity. The stoichiometry and binding constant of the complex were determined by Scott’s method.

Keywords

Desloratadine β-Cyclodextrin Inclusion complex NMR spectroscopy ROESY COSY 

Notes

Acknowledgement

We are grateful to the Prof. James M. Coxon, Dr. Axel T. Neffe and his team, University of Canterbury, Christchurch, New Zealand, for help in obtaining some of the NMR data. We are also grateful to Morpen Laboratories Ltd., India, for providing pure sample of desloratadine.

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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Syed Mashhood Ali
    • 1
  • Santosh Kumar Upadhyay
    • 1
  • Arti Maheshwari
    • 1
  1. 1.Department of ChemistryAligarh Muslim UniversityAligarhIndia

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