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Crystal and molecular structure of β-cyclodextrin inclusion complex with succinic acid

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Abstract

The crystal complex of β-cyclodextrin with succinic acid, intermediate product of hydrolysis reaction of succinic anhydride in the presence of β-cyclodextrin, was isolated and studied by X-ray analysis (monoclinic, space group P21, a = 15.1977(7) Å, b = 10.1763(5) Å, c = 20.6943(6) Å, β = 109.239(4)°, V = 3021.8(2) Å3, Z = 2, R 1 = 0.0359, wR 2 = 0.0947). It was proved that β-cyclodextrin and succinic acid form an inclusion complex, which exists in crystal state as a heptahydrate. The molecule of succinic acid is fully included in the β-cyclodextrin cavity with its carboxyl groups accessible for water molecules. Water molecules located at borders of cavity rims and in interstices between molecules of β-cyclodextrin participate in formation of intermolecular hydrogen bonds. The overall structure does not contain disordered fragments. The crystal conformation of succinic acid corresponds to one of possible conformers of the molecule in vacuo and is almost not disturbed by intermolecular interactions in crystal. Based on the analysis of structural features of the crystal conformation of succinic acid and character of its location in the β-cyclodextrin cavity, it was suggested that hydrolysis of succinic anhydride via ring opening and formation of succinic acid is mediated by cyclodextrin microenvironment and it likely occurs near the narrow rim of the macrocycle cavity.

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Acknowledgements

This work was supported by National Academy of Sciences of Ukraine. VB acknowledges the ICDD for financial support (Grant (03-02).

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Authors and Affiliations

  1. Department of Molecular Modeling, I.Mechnikov Institute of Microbiology and Immunology AMS of Ukraine, 14/16 Pushkinskaya St., Kharkov, 61057, Ukraine

    Yuriy V. Lisnyak & Arthur V. Martynov

  2. STC “Institute for Single Crystals” NAS of Ukraine, 60 Lenin Ave., Kharkov, 61001, Ukraine

    Vyacheslav N. Baumer & Oleg V. Shishkin

  3. New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ, 08854, USA

    Anna V. Gubskaya

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  1. Yuriy V. Lisnyak
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Correspondence to Arthur V. Martynov.

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10847_2006_9284_MOESM1_ESM.pdf

CCDC 617335 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB2 1EZ,UK; fax: +44 1223 336033 (PDF 13 kb)

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Lisnyak, Y.V., Martynov, A.V., Baumer, V.N. et al. Crystal and molecular structure of β-cyclodextrin inclusion complex with succinic acid. J Incl Phenom Macrocycl Chem 58, 367–375 (2007). https://doi.org/10.1007/s10847-006-9284-x

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  • DOI: https://doi.org/10.1007/s10847-006-9284-x

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