Fluorescent cyclodextrins bearing metal binding sites and their use for chemo- and enantioselective sensing of amino acid derivatives
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Ditopic receptors based on cyclodextrins bearing a metal binding site were used as enantioselective fluorescence sensors, which were able to generate different responses in the presence of d- or l-amino acids. The performances of the selectors as a function of their structure were evaluated, and the same analysis was extended to other analytes. In this work, this approach is used for the enantiomers of a series of amino acid derivatives and in particular of 2-aminocaprolactam. The results showed that the ability of these sensors to perform enantiomeric analysis can be extended to other analytes of interest in organic synthesis such as amino acid amides and α-aminolactams.
KeywordsFluorescent sensors Enantioselectivity Amino acids derivatives Cyclodextrins
This work was partially supported by DSM and by grants from the Ministero dell’Istruzione, Università e Ricerca (PRIN2005 project: “Molecular and enantiomeric recognition of biologically active substances in natural systems”, and FIRB project RBNE01KZZM_006: “Study of multifunctional microsystems for chemical and biochemical determinations in complex biological matrixes.”).
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