Abstract
The spectral displacement method in presence of methyl orange has been coupled to the continuous variation plot to allow the determination of the stoichiometries for inclusion compounds. Such a “competitive continuous variation plot” (CCV plot) is especially useful for the study of substrates which are not directly observable by spectroscopy or which are too poorly soluble to give observable signals. Moreover, when a mixture of complexes is observed, the position of the maximum in the competitive continuous variation plot gives information on the relative affinities of the complexes, which is not the case in the classical Job plot which also depends of the intrinsic spectral characteristics of each complex. The method is not restricted to β-cyclodextrin inclusion compounds, and it may be applied to any complexes if an appropriate competitive system is available.
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Abbreviations
- CCV:
-
Competitive Continuous Variation
- βCD:
-
β-Cyclodextrin
- CD:
-
Cyclodextrin
- MO:
-
Methyl orange
- S:
-
Substrate
- SBE1:
-
Sulfobutylated β-cyclodextrin, mean degree equal to 1
- SBE7:
-
Sulfobutylated β-cyclodextrin, mean degree equal to 7
References
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Landy, D., Tetart, F., Truant, E. et al. Development of a competitive continuous variation plot for the determination of inclusion compounds stoichiometry. J Incl Phenom Macrocycl Chem 57, 409–413 (2007). https://doi.org/10.1007/s10847-006-9226-7
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DOI: https://doi.org/10.1007/s10847-006-9226-7