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Calculation of cyclodextrin-mediated enantiomer ratio shifting of racem norgestrel in aqueous solutions

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Abstract

Enantioselective solubility of rac-norgestrel was found in the presence of γ-cyclodextrin or hydroxypropyl-γ-cyclodextrin. In both cases the efficacious enantiomer was dissolved in greater extent. Calculating the molar absorptivity and molar ellipticity spectra of the γ- and hydroxypropyl-γ-cyclodextrin aqueous complexes, a simple and rapid direct circular dichroism (CD) spectrometric method was obtained for the determination of the enantiomer ratio in aqueous solutions.

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Acknowledgments

This work was supported by the Hungarian Science Found (OTKA) under the grant number T048554. The valuable contribution of Ilona Matalin-Foór is highly appreciated.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. Street 9, H-1092, Budapest, Hungary

    Dávid Szegvári, Péter Horváth & András Gergely

  2. University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. Street 9, H-1092, Budapest, Hungary

    Romána Zelkó

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  1. Dávid Szegvári
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  2. Romána Zelkó
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  3. Péter Horváth
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  4. András Gergely
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Correspondence to András Gergely.

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Szegvári, D., Zelkó, R., Horváth, P. et al. Calculation of cyclodextrin-mediated enantiomer ratio shifting of racem norgestrel in aqueous solutions. J Incl Phenom Macrocycl Chem 57, 169–172 (2007). https://doi.org/10.1007/s10847-006-9199-6

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  • DOI: https://doi.org/10.1007/s10847-006-9199-6

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