Circular dichroism and theoretical studies on the inclusion of the antimalarian drug Licochalcone-A in β-cyclodextrin
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The Induced Circular Dichroism of the complex formed by inclusion of Licochalcone-A (a powerful antimalarian of natural origin) and β-cyclodextrin was measured and calculated. The association constant was determined by titration experiments of ICD and fluorescence. The lowest energy conformations of the complex were obtained through docking procedures and their Circular Dichroism was evaluated within the Tinoco framework. The geometry of the complex was found to be consistent with the main experimental features.
KeywordsLicochalcone Malaria Circular Dichroism
- 1.Renan, R.: Identification of the traditional chinese materia medica, Shangai Scientific and Technical Pub. House, Shangai, People’s Republic of China (1986)Google Scholar
- 3.Chen, M., Theander, T., Christensen, S.B., Hvid, L., Zhai, L., Kharazmi, A.: Licochalcone-A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protect mice from P. yoellii infection. Antimicrob. Agents Chemother. 38, 1470–1475 (1994)Google Scholar
- 4.Chen, M., Christensen, S.B., Blom, J., Lemmich, E., Nadelmann, L., Fich, K., Theander, T.G., Kharazmi, A.: Licochalcone-A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania. Antimicrob. Agents Chemother. 37, 2550–2556 (1993)Google Scholar
- 5.InsightII, Accelrys Software Inc., San Diego (2005)Google Scholar