Recent Aspect of Cyclodextrin-Based Drug Delivery System
- 457 Downloads
The pharmaceutically useful cyclodextrins (CyDs) are classified into hydrophilic, hydrophobic, and ionic derivatives. These CyDs can serve as multi-functional drug carriers, through the formation of inclusion complex or the form of CyD/drug conjugate. In addition, the combined use of different CyDs and/or pharmaceutical excipients is capable of alleviating the undesirable properties of drug molecules, improving efficacy and reducing side effects. This contribution outlines the potential use of CyDs in the design and evaluation of CyD-based drug formulation, focusing on their ability to enhance the drug absorption across biological barriers, the ability to control the rate and time profiles of drug release, and the ability to deliver a drug to targeted site.
Keywordsabsorption enhancement conjugate controlled drug release cyclodextrin drug carrier inclusion complex pharmaceutical formulation targeting
Unable to display preview. Download preview PDF.
- 5.Davis M.E., Brewster M.E., Nat. Rev. 3, 1023 (2004) Google Scholar
- 6.Szejtli J., Cyclodextrin News 18(1), 1 (2004)Google Scholar
- 7.Thompson D.O., CRC Crit. Rev. Ther. Drug Carrier Syst. 14, 1 (1997)Google Scholar
- 11.Arima H., Yunomae K., Hirayama F., Uekama K., J. Pharmacol. Exp. Ther. 297, 547 (2001)Google Scholar
- 14.Wang Z., Hirayama F., Uekama K., J. Pharm. Pharmacol. 46, 505 (1994)Google Scholar
- 21.Wada K., Arima H., Tsutsumi T., Chihara Y., Hattori K., Hirayama F., Uekama K., J. Control. Rel. 104, 397 (2005)Google Scholar