Journal of Interventional Cardiac Electrophysiology

, Volume 34, Issue 3, pp 219–225 | Cite as

Survival advantage from ventricular fibrillation and pulseless electrical activity in women compared to men: the Oregon Sudden Unexpected Death Study

  • Carmen Teodorescu
  • Kyndaron Reinier
  • Audrey Uy-Evanado
  • Jo Ayala
  • Ronald Mariani
  • Lynn Wittwer
  • Karen Gunson
  • Jonathan Jui
  • Sumeet S. Chugh



Studies evaluating a possible survival advantage from sudden cardiac arrest (SCA) in women have produced mixed results possibly due to a lack of comprehensive analyses. We hypothesized that race, socioeconomic status (SES), and elements of the lifetime clinical history influence gender effects and need to be incorporated within analyses of survival.


Cases of SCA were identified from the ongoing, prospective, multiple-source Oregon Sudden Unexpected Death Study (population approximately one million). Subjects included were age ≥18 years who underwent attempted resuscitation by EMS providers. Pearson’s chi-square tests and independent samples t tests or analysis of variance were used for univariate comparisons. We evaluated gender and race differences in survival adjusted for age, circumstances of arrest, disease burden, and socioeconomic status using a logistic regression model predicting survival.


A total of 1,296 cases had resuscitation attempted (2002–2007; mean age 65 years, male 67%). Women were older than men (68 vs. 63 years, p < 0.0001) and were more likely to have return of spontaneous circulation (41% vs. 33%, p = 0.004). Women were more likely to present with pulseless electrical activity (PEA) and asystole (p < 0.0001), and overall, PEA was more common among African Americans (p = 0.04). Higher survival to hospital discharge was observed in women compared to men presenting with ventricular fibrillation/tachycardia (34% vs. 24%, p = 0.02) or with PEA (10% vs. 3%, p = 0.007). In a multivariate model adjusting for age, race, presenting arrhythmia, arrest circumstances, arrest location, disease burden, and SES, women were more likely than men to survive to hospital discharge [odds ratio 1.85; 95% confidence interval (1.12–3.04)].


Despite older age, higher prevalence of SCA in the home, and higher rates of PEA, women had a survival advantage from ventricular fibrillation and pulseless electrical activity.


Sudden cardiac arrest Survival Women Pulseless electrical activity Ventricular fibrillation Resuscitation 



The authors would like to acknowledge the significant contribution of American Medical Response, Portland/Gresham fire departments, and the Oregon State Medical Examiner’s office. This study was funded in part by the National Heart Lung and Blood Institute R01HL088416, R01 HL088416-03S1, and R01 HL105170 to Dr. Chugh. This work was also supported by an Award from the American Heart Association and Philips Healthcare to Dr. Teodorescu. Dr. Chugh is the Pauline and Harold Price Professor of Cardiac Electrophysiology at the Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.

Conflict of interest



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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Carmen Teodorescu
    • 1
  • Kyndaron Reinier
    • 1
  • Audrey Uy-Evanado
    • 1
  • Jo Ayala
    • 1
  • Ronald Mariani
    • 1
  • Lynn Wittwer
    • 2
  • Karen Gunson
    • 3
  • Jonathan Jui
    • 4
  • Sumeet S. Chugh
    • 1
  1. 1.The Heart InstituteCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.PeaceHealth Southwest Medical Center and Clark County EMSVancouverUSA
  3. 3.Department of PathologyOregon Health and Science UniversityPortlandUSA
  4. 4.Emergency MedicineOregon Health and Science UniversityPortlandUSA

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