Regenerative therapies in electrophysiology and pacing: introducing the next steps



The morbidity and mortality of cardiac arrhythmias are major international health concerns. Drug and device therapies have made inroads but alternative approaches are still being sought. For example, gene and cell therapies have been explored for treatment of brady- and tachyarrhythmias, and proof of concept has been obtained for both biological pacing in the setting of heart block and gene therapy for ventricular tachycardias. This paper reviews the state of the art developments with regard to gene and cell therapies for cardiac arrhythmias and discusses next steps.


Gene therapy Cell therapy Arrhythmias 



Certain experiments referred to were supported by USPHS-NHLBI grants Hl-28968, HL-67101, and HL-094410 and NYSTEM contract number CO24344. Gerard Boink received a research grant from the Netherlands Foundation for Cardiovascular Research (NFCVR) and fellowship grants from the Dr. Saal van Zwanenberg foundation and the Interuniversity Cardiology Institute of the Netherlands (ICIN).


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Heart Failure Research CenterAcademic Medical CenterAmsterdamNetherlands
  2. 2.Interuniversity Cardiology Institute of the Netherlands (ICIN)UtrechtNetherlands
  3. 3.Department of PharmacologyColumbia UniversityNew YorkUSA
  4. 4.Department of PediatricsColumbia UniversityNew YorkUSA
  5. 5.Center for Molecular TherapeuticsColumbia UniversityNew YorkUSA

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