AMPA/NMDA cooperativity and integration during a single synaptic event
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Coexistence of AMPA and NMDA receptors in glutamatergic synapses leads to a cooperative effect that can be very complex. This effect is dependent on many parameters including the relative and absolute number of the two types of receptors and biophysical parameters that can vary among synapses of the same cell. Herein we simulate the AMPA/NMDA cooperativity by using different number of the two types of receptors and considering the effect of the spine resistance on the EPSC production. Our results show that the relative number of NMDA with respect to AMPA produces a different degree of cooperation which depends also on the spine resistance.
KeywordsAMPA NMDA Glutamatergic synapse Synaptic model Spine resistance AMPA/NMDA cooperativity LPT
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The authors declare that they have no conflict of interest.
- Di Maio, V., Ventriglia, F., & Santillo, S. (2016a). A model of cooperative effect of AMPA and NMDA receptors in glutamatergic synapses. Cognitive Neurodynamics. doi: 10.1007/s11571-016-9383-3.
- Di Maio, V., Ventriglia, F., & Santillo, S. (2016b). A model of Dopamine modulation of glutamatergic synapse on medium size spiny neurons. Biosystems. doi: 10.1016/j.biosystems.2016.03.001.
- Segev, I. (1998). Cable and compartmental models of dendritic trees. In Bower, J M, & Beeman, D (Eds.), The book of GENESIS: exploring realistic neural models with the general, neural, simulation systems (pp. 51–78). Whiley.Google Scholar
- Ventriglia, F., & Di Maio, V. (2000a). A Brownian simulation model of glutamate synaptic diffusion in the femtosecond time scale. Biological Cybernetics, 83, 93–109.Google Scholar
- Ventriglia, F., & Di Maio, V. (2000b). A Brownian model of glutamate diffusion in excitatory synapses of hippocampus. Biosystems, 58, 67–74.Google Scholar
- Ventriglia, F., & Di Maio, V. (2013a). Effects of AMPARs trafficking and glutamate-receptor binding probability on stochastic variability of EPSC. Biosystems, 112, 298–304.Google Scholar
- Ventriglia, F., & Di Maio, V. (2013b). Glutamate-AMPA interaction in a model of synaptic transmission. Brain Research, 1536, 168–176.Google Scholar
- Zito, K., & Scheuss, V. (2009). NMDA receptor function and physiological modulation. In Squire, L (Ed.), Encyclopedia of neuroscience, (Vol. 6 pp. 1157–1164). Oxford: Academic Press.Google Scholar
- Zuber, B., Nikonenko, I., Klauser, P., Muller, D., & Dobochet, J. (2005). The mammallian central nervous synaptic cleft contains a high density of periodically organized complexes. Proceedings of the National Academy of Sciences of the United States of America, 102, 19,192–19,197.CrossRefGoogle Scholar