A simple integrative electrophysiological model of bursting GnRH neurons
In this paper a modular model of the GnRH neuron is presented. For the aim of simplicity, the currents corresponding to fast time scales and action potential generation are described by an impulsive system, while the slower currents and calcium dynamics are described by usual ordinary differential equations (ODEs). The model is able to reproduce the depolarizing afterpotentials, afterhyperpolarization, periodic bursting behavior and the corresponding calcium transients observed in the case of GnRH neurons.
KeywordsGonadotropin-releasing hormone dynamic modelling bursting
This work was supported by the National Science Foundation of Hungary K69127, K67625, and T73002) and the Hungarian Health Research Council Fund (122/2009). The research leading to these results has received funding from the European Community’s Seventh Framework Program (FP7/ 2007-2013) under Grant Agreement 245009. The authors would like to thank Katalin Hangos for her contribution.
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