Recent publications suggested that the risk for pre-eclampsia (PE) is higher with frozen-thawed embryo transfers (FETs) compared to fresh transfers (IVF-ETs). These studies were based on old data that reflects outdated practices. In this paper, we wanted to assess the incidence of PE in current assisted reproductive technology (ART) practice.
In this cohort study, we present the incidence of PE in all births in the province of Ontario, Canada, for the years 2013–2017 for FET, IVF-ET, and natural conceptions (NC). We also compare our findings to previous studies in a meta-analysis that includes over 4 million births.
The results of our study show that contemporary practice of ART results in comparable risk for PE between FET and IVF-ET; however, the risk is higher than NC.
Current ART practice is associated with a lower risk for PE in frozen embryo transfer; this RR can be further attenuated by using ovulatory endometrial preparation for FETs.
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We wish to acknowledge the Better Outcomes Registry and Network (BORN) Ontario as the source of the data and CARTR Plus for providing Extract ART and birth data (Years provided: 2013 to 2017). The data was provided in 2020.
The study was funded internally.
All inferences, opinions, and conclusions drawn in this publication are those of the authors, and do not necessarily reflect the options or policies of BORN Ontario.
Conflict of interest
The authors declare that they have no conflict of interest.
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Kenigsberg, S., Bentov, Y. Does contemporary ART lead to pre-eclampsia? A cohort study and meta-analysis. J Assist Reprod Genet (2021). https://doi.org/10.1007/s10815-021-02061-z
- Hypertensive disorders of pregnancy
- Frozen embryo transfer
- Fresh embryo transfer
- Natural conception
- Assisted reproductive technology