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Connecting links between genetic factors defining ovarian reserve and recurrent miscarriages

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Abstract

Purpose

Approximately 1–2% of the women faces three or more successive spontaneous miscarriages termed as recurrent miscarriage (RM). Many clinical factors have been attributed so far to be the potential risk factors in RM, including uterine anomalies, antiphospholipid syndrome, endocrinological abnormalities, chromosomal abnormalities, and infections. However, in spite of extensive studies, reviews, and array of causes known to be associated with RM, about 50% cases encountered by treating physicians remains unknown. The aims of this study were to evaluate recent publications and to explore oocyte-specific genetic factors that may have role in incidence of recurrent miscarriages.

Method

Recent studies have identified common molecular factors contributing both in establishment of ovarian reserve and in early embryonic development. Also, studies have pointed out the relationship between the age-associated depletion of OR and increase in the risk of miscarriages, thus suggestive of an interacting biology. Here, we have gathered literature evidences in establishing connecting links between genetic factors associated with age induced or pathological OR depletion and idiopathic RM, which are the two extreme ends of female reproductive pathology.

Conclusion

In light of connecting etiological link between infertility and RM as reviewed in this study, interrogating the oocyte-specific genes with suspected roles in reproductive biology, in cases of unexplained RM, may open new possibilities in widening our understanding of RM pathophysiology.

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Acknowledgments

The author is thankful Council of Science and Industrial Research (CSIR)–New Delhi for providing her fellowship.

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  1. Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, U.P., 226014, India

    Deepika Delsa Dean, Sarita Agarwal & Poonam Tripathi

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  1. Deepika Delsa Dean
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  2. Sarita Agarwal
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Correspondence to Sarita Agarwal.

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Dean, D.D., Agarwal, S. & Tripathi, P. Connecting links between genetic factors defining ovarian reserve and recurrent miscarriages. J Assist Reprod Genet 35, 2121–2128 (2018). https://doi.org/10.1007/s10815-018-1305-3

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