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Associations of semen quality with non-essential heavy metals in blood and seminal fluid: data from the Environment and Male Infertility (EMI) study in Lebanon

  • Reproductive Physiology and Disease
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Background

Human exposure to environmental pollutants is widespread. It was suggested that exposure to non-essential heavy metals may adversely affect semen development in men.

Purpose

To evaluate associations between non-essential heavy metals in blood and seminal fluid and semen quality parameters in men.

Methods

Male partners of heterosexual couples were included. The following elements were measured in blood and seminal fluid: lead (Pb), cadmium (Cd), arsenic (As), barium (Ba), mercury (Hg), and uranium (U) using ion-coupled plasma-mass spectrometry.

Setting

The fertility clinic at the American University of Beirut Medical Center.

Main outcome measures

Semen quality parameters (volume, concentration, total count, progressive motility, viability, and normal morphology).

Results

We found that participants with low-quality semen had significantly higher Cd and Ba concentrations in the seminal fluid than participants with normal-quality semen. We also observed significant associations between low sperm viability and higher blood Cd and Ba, as well as higher seminal Pb, Cd, Ba, and U. Furthermore, U concentrations in the seminal fluid were associated with increased odds ratios for below-reference progressive sperm motility and normal morphology.

Conclusions

Environmental exposures to Pb, Cd, Ba, and U appear to adversely influence sperm development in men. In non-occupationally exposed men, measurements of heavy metals in the seminal fluid may be more predictive of below-reference sperm quality parameters than in blood.

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Author notes

  1. Joint first authorship with equal contribution (Carol Sukhn and Johnny Awwad).

Authors and Affiliations

  1. Environment Core Laboratory, Department of Pathology and Laboratory Medicine, Faculty of Medicine, American University of Beirut Medical Center, American University of Beirut, PO Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon

    Carol Sukhn & Ghazi Zaatari

  2. Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

    Johnny Awwad

  3. Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon

    Akram Ghantous

Authors
  1. Carol Sukhn
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  2. Johnny Awwad
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  3. Akram Ghantous
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  4. Ghazi Zaatari
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Corresponding author

Correspondence to Ghazi Zaatari.

Ethics declarations

This study was approved by the American University of Beirut Institutional Review Board, and all eligible participants signed an informed consent form prior to enrollment.

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Sukhn, C., Awwad, J., Ghantous, A. et al. Associations of semen quality with non-essential heavy metals in blood and seminal fluid: data from the Environment and Male Infertility (EMI) study in Lebanon. J Assist Reprod Genet 35, 1691–1701 (2018). https://doi.org/10.1007/s10815-018-1236-z

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  • DOI: https://doi.org/10.1007/s10815-018-1236-z

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