Journal of Assisted Reproduction and Genetics

, Volume 35, Issue 8, pp 1401–1406 | Cite as

Embryoscopy and karyotype findings of repeated miscarriages in recurrent pregnancy loss and spontaneous pregnancy loss

  • M. Feichtinger
  • A. Reiner
  • B. Hartmann
  • T. PhilippEmail author
Reproductive Physiology and Disease



The aim of the study was to assess cytogenetic and embryoscopic characteristics in subsequent miscarriages of spontaneous pregnancy losses (SPL) and recurrent pregnancy losses (RPL).


A retrospective cohort of 75 women was affected by repeated pregnancy loss. Of those, 34 had SPL, 24 primary RPL, and 17 secondary RPL. Ploidy status and morphology was analyzed by transcervical embryoscopic examination of the embryo and cytogenetic analysis of the chorionic villi in subsequent miscarriages.


Similar rates of recurrent ploidy status were observed between first and second miscarriage in SPL and RPL (82.4% recurrent ploidy status in SPL, p > 0.999; 73% recurrent ploidy status in RPL, p = 0.227). No difference was found regarding recurrent abnormal morphology between SPL and RPL (p = 0.092). However, secondary RPL resulted significantly more often in recurrent abnormal morphology compared to primary RPL (p = 0.004).


High rates of recurrent normal/abnormal karyotypes were observed in all groups with a majority of embryos presenting with recurrent abnormal morphology. Secondary RPL presented significantly more often with recurrent abnormal morphology compared to primary RPL. These findings offer prognostic information for the affected patient and might impact treatment choice.


Abnormal embryonic development Chromosome abnormalities Missed abortion Transcervical embryoscopy Repeated pregnancy loss 


Author contributions

TP performed all embryoscopic investigations; AR performed all cytogenetic analysis; BH critically reviewed the manuscript and provided expert opinion. MF wrote the manuscript and performed the statistical analysis; all authors critically revised the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • M. Feichtinger
    • 1
    • 2
    • 3
  • A. Reiner
    • 4
  • B. Hartmann
    • 5
  • T. Philipp
    • 5
    Email author
  1. 1.Department of Obstetrics and Gynecology, Division of Gynecologic Endocrinology and Reproductive MedicineMedical University of ViennaViennaAustria
  2. 2.Wunschbaby Institut FeichtingerViennaAustria
  3. 3.Department of Oncology – PathologyKarolinska InstitutetStockholmSweden
  4. 4.Department of Pathology, Cytogenetic LaboratoryDanube HospitalViennaAustria
  5. 5.Department of Obstetrics and GynecologyDanube HospitalViennaAustria

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