Journal of Assisted Reproduction and Genetics

, Volume 35, Issue 6, pp 1039–1046 | Cite as

Mode of conception does not affect fetal or placental growth parameters or ratios in early gestation or at delivery

  • Lauren W. Sundheimer
  • Jessica L. Chan
  • Rae Buttle
  • Rosemarie DiPentino
  • Olivia Muramoto
  • Kerlly Castellano
  • Erica T. Wang
  • John WilliamsIII
  • Margareta D. Pisarska
Assisted Reproduction Technologies



Ratio of fetal weight to placenta size varies by mode of conception (fertility treatments utilized) in animals. Our objective was to assess whether fertility treatments also affect these ratios in humans.


In this retrospective study, we assessed two cohorts: (a) early gestation cohort, women with singleton pregnancies who underwent first trimester vaginal ultrasound and (b) delivered cohort, women who delivered a live-born, singleton infant with placenta disposition to pathology. Crown rump length (CRL) and estimated placental volume (EPV) were calculated from first trimester ultrasound images using a validated computation. Infant birth weight (BW), pregnancy data, placental weight (PW), and placental histopathology were collected. Fetal growth-to-placental weight ratios (CRL/EPV; BW/PW) and placentas were compared by mode of conception. Linear regression was used to adjust for confounding variables.


Two thousand one hundred seventy patients were included in the early gestation cohort and 1443 in the delivered cohort. Of the early gestation cohort (a), 85.4% were spontaneous conceptions, 5.9% Non-IVF Fertility (NIFT), and 8.7% IVF. In the delivered cohort (b), 92.4% were spontaneous, 2.1% NIFT, and 80 5.5% IVF. There were no significant differences between fetal growth-to-placental weight parameters, ratios, and neonatal birth measurements based on mode of conception. Placenta accreta was significantly higher in the patients receiving fertility treatments (1.2 versus 3.6%, p < 0.05).


Mode of conception does not appear to influence fetal growth-to-placental weight ratios throughout gestation. In addition, findings in animal models may not always translate into human studies of infertility treatment outcomes.


Fertility treatment Crown rump length Estimated placental volume Birth weight Placental weight 


Funding information

This study was funded through the National Institutes of Health (R01HD074368).

Compliance with ethical standards

The Institutional Review Board of Cedars-Sinai Medical Center in Los Angeles approved the study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Lauren W. Sundheimer
    • 1
    • 2
  • Jessica L. Chan
    • 1
  • Rae Buttle
    • 1
  • Rosemarie DiPentino
    • 1
  • Olivia Muramoto
    • 1
  • Kerlly Castellano
    • 1
  • Erica T. Wang
    • 1
    • 2
  • John WilliamsIII
    • 2
    • 3
  • Margareta D. Pisarska
    • 1
    • 2
  1. 1.Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and InfertilityCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  3. 3.Department of Obstetrics and Gynecology, Division of Maternal Fetal MedicineCedars-Sinai Medical CenterLos AngelesUSA

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