Skip to main content
Log in

Do trained reproductive endocrinologists perform better than their trainees? Comparing clinical pregnancy rates and live birth rates after transfer of single fresh blastocysts

  • Assisted Reproduction Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To compare clinical pregnancy rates and live birth rates of single blastocyst transfers performed by attending physicians or fellows in reproductive endocrinology and infertility program.

Methods

Retrospective study in an academic reproductive center. We evaluated 932 fresh single blastocyst transfer cycles performed by fellows in training (389 embryo transfers) and by attending physicians (543 embryo transfers).

Results

There were no differences in the baseline characteristics and IVF cycle parameters between patients who had transfers performed by fellows or attending physicians. Transfers performed by attending physicians or fellows resulted in similar CPR (46.5 vs. 42.9%, p = 0.28) and LBR (38.3 vs. 34.2%, p = 0.11). Multivariate logistic regression analysis showed that even after adjusting for possible confounders (age, gravity, parity, baseline FSH, antral follicle count, dose of gonadotropins, stimulation protocol, and quality of embryo transferred), CPR (OR 0.81, CI 0.62–1.07) and LBR (OR 0.79, CI 0.6–1.05) in the two groups were comparable.

Conclusion

Clinical pregnancy rate and live birth rate after embryo transfer performed by attending staffs or fellows are comparable. This finding reassures fellowship programs that allowing fellows to perform embryo transfers does not compromise the outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Kocourkova J, Burcin B, Kucera T. Demographic relevancy of increased use of assisted reproduction in European countries. Reprod Health. 2014;11:37.

    Article  PubMed  PubMed Central  Google Scholar 

  2. de Ziegler D, de Ziegler N, Sean S, Bajouh O, Meldrum DR. Training in reproductive endocrinology and infertility and assisted reproductive technologies: options and worldwide needs. Fertil Steril. 2015;104:16–23.

    Article  PubMed  Google Scholar 

  3. Zenke U, Chetkowski RJ. Transfer and uterine factors are the major recipient-related determinants of success with donor eggs. Fertil Steril. 2004;82:850–6.

    Article  PubMed  Google Scholar 

  4. Brown J, Buckingham K, Buckett W, Abou-Setta AM. Ultrasound versus ‘clinical touch’ for catheter guidance during embryo transfer in women. Cochrane Database Syst Rev. 2016;3:Cd006107.

    PubMed  Google Scholar 

  5. Schoolcraft WB. Importance of embryo transfer technique in maximizing assisted reproductive outcomes. Fertil Steril. 2016;105:855–60.

    Article  PubMed  Google Scholar 

  6. Samara N, Reis D, Danielli Miller N, Ghetler Y, Berkovitz A, Miller M, et al. What are the best predictors for successful GnRH antagonist protocol in in vitro fertilization (IVF) treatment? Gynecol Endocrinol. 2015;31:877–9.

    Article  PubMed  CAS  Google Scholar 

  7. Tomas C, Tikkinen K, Tuomivaara L, Tapanainen JS, Martikainen H. The degree of difficulty of embryo transfer is an independent factor for predicting pregnancy. Hum Reprod. 2002;17:2632–5.

    Article  PubMed  Google Scholar 

  8. Dessolle L, Freour T, Barriere P, Jean M, Ravel C, Darai E, et al. How soon can I be proficient in embryo transfer? Lessons from the cumulative summation test for learning curve (LC-CUSUM). Hum Reprod. 2010;25:380–6.

    Article  PubMed  Google Scholar 

  9. Omidi M, Halvaei I, Mangoli E, Khalili MA, Razi MH. The effect of embryo catheter loading technique on the live birth rate. Clin Exp Reprod Med. 2015;42:175–80.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Wittenberger MD, Catherino WH, Armstrong AY. Role of embryo transfer in fellowship training. Fertil Steril. 2007;88:1014–5.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Eaton JL, Zhang X, Barnes RB. Embryo transfer by reproductive endocrinology fellows vs attending physicians: are live birth rates comparable? Am J Obstet Gynecol. 2014;211:494.e1–5.

    Article  Google Scholar 

  12. Lopez MJ, Garcia D, Rodriguez A, Colodron M, Vassena R, Vernaeve V. Individualized embryo transfer training: timing and performance. Hum Reprod. 2014;29:1432–7.

    Article  PubMed  Google Scholar 

  13. Shah DK, Missmer SA, Correia KF, Racowsky C, Ginsburg E. Efficacy of intrauterine inseminations as a training modality for performing embryo transfer in reproductive endocrinology and infertility fellowship programs. Fertil Steril. 2013;100:386–91.

    Article  PubMed  Google Scholar 

  14. Menezo Y, Anker D, Salat-Baroux J. Conception and realization of artificial dyed embryos for training in in vitro fertilization and embryo transfer (IVF and ET). Acta Eur Fertil. 1985;16:55–8.

    PubMed  CAS  Google Scholar 

  15. Teixeira DM, Dassuncao LA, Vieira CV, Barbosa MA, Coelho Neto MA, Nastri CO, et al. Ultrasound guidance during embryo transfer: a systematic review and meta-analysis of randomized controlled trials. Ultrasound Obstet Gynecol. 2015;45:139–48.

    Article  PubMed  CAS  Google Scholar 

  16. Yao Z, Vansteelandt S, Van der Elst J, Coetsier T, Dhont M, De Sutter P. The efficacy of the embryo transfer catheter in IVF and ICSI is operator-dependent: a randomized clinical trial. Hum Reprod. 2009;24:880–7.

    Article  PubMed  Google Scholar 

  17. Urbina MT, Benjamin I, Medina R, Lerner J. Echogenic catheters and embryo transfer standardization. JBRA Assist Reprod. 2015;19:75–82.

    PubMed  Google Scholar 

  18. Gardner DK, Surrey E, Minjarez D, Leitz A, Stevens J, Schoolcraft WB. Single blastocyst transfer: a prospective randomized trial. Fertil Steril. 2004;81:551–5.

    Article  PubMed  CAS  Google Scholar 

  19. Oron G, Son WY, Buckett W, Tulandi T, Holzer H. The association between embryo quality and perinatal outcome of singletons born after single embryo transfers: a pilot study. Hum Reprod. 2014;29:1444–51.

    Article  PubMed  Google Scholar 

  20. Hosmer DW Lemeshow S, Sturdivant RX. Applied logistic regression. 3 ed, 2013.

  21. Papageorgiou TC, Hearns-Stokes RM, Leondires MP, Miller BT, Chakraborty P, Cruess D, et al. Training of providers in embryo transfer: what is the minimum number of transfers required for proficiency? Hum Reprod. 2001;16:1415–9.

    Article  PubMed  CAS  Google Scholar 

  22. Barber D, Egan D, Ross C, Evans B, Barlow D. Nurses performing embryo transfer: successful outcome of in-vitro fertilization. Hum Reprod. 1996;11:105–8.

    Article  PubMed  CAS  Google Scholar 

  23. Barber D, Barlow D, Balen A. Fertility nurses doing embryo transfers—what is the impact of training? Hum Fertil (Camb). 2000;3:181–5.

    Article  Google Scholar 

  24. Sinclair L, Morgan C, Lashen H, Afnan M, Sharif K. Nurses performing embryo transfer: the development and results of the Birmingham experience. Hum Reprod. 1998;13:699–702.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sadikah Behbehani.

Ethics declarations

The Research and Ethics Board of the McGill University Health Centre approved the study (Study 15-249).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Behbehani, S., Hasson, J., Polesello, S. et al. Do trained reproductive endocrinologists perform better than their trainees? Comparing clinical pregnancy rates and live birth rates after transfer of single fresh blastocysts. J Assist Reprod Genet 35, 885–890 (2018). https://doi.org/10.1007/s10815-018-1127-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10815-018-1127-3

Keywords

Navigation