Journal of Assisted Reproduction and Genetics

, Volume 35, Issue 3, pp 355–366 | Cite as

Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss

  • Luis Alejandro Arias-Sosa
  • Iván Darío Acosta
  • Elkin Lucena-Quevedo
  • Harold Moreno-Ortiz
  • Clara Esteban-Pérez
  • Maribel Forero-Castro


Recurrent pregnancy loss (RPL) is a reproductive disorder defined as two or more successive and spontaneous pregnancy losses (before 20 weeks of gestation), which affects approximately 1–2% of couples. At present, the causes of RPL remain unknown in a considerable number of cases, leading to complications in treatment and high levels of stress in couples. Idiopathic recurrent pregnancy loss (iRPL) has become one of the more complicated reproductive problems worldwide due to the lack of information about its etiology, which limits the counseling and treatment of patients. For that reason, iRPL requires further study of novel factors to provide scientific information for determining clinical prevention and targeted strategies. The aim of this study is to describe the most recent and promising progress in the identification of potential genetic and epigenetic risk factors for iRPL, expanding the genetic etiology of the disease.


Epigenetic Genetic Idiopathic recurrent pregnancy loss Immune tolerance Thrombophilia Tissue remodeling 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


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Authors and Affiliations

  • Luis Alejandro Arias-Sosa
    • 1
  • Iván Darío Acosta
    • 1
  • Elkin Lucena-Quevedo
    • 2
  • Harold Moreno-Ortiz
    • 2
  • Clara Esteban-Pérez
    • 2
  • Maribel Forero-Castro
    • 1
  1. 1.School of Biological ScienceUniversidad Pedagógica y Tecnológica de ColombiaTunjaColombia
  2. 2.Department of Reproductive Genetic, Fertility and Sterility Colombian Center (CECOLFES)BogotáColombia

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