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Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss

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Abstract

Recurrent pregnancy loss (RPL) is a reproductive disorder defined as two or more successive and spontaneous pregnancy losses (before 20 weeks of gestation), which affects approximately 1–2% of couples. At present, the causes of RPL remain unknown in a considerable number of cases, leading to complications in treatment and high levels of stress in couples. Idiopathic recurrent pregnancy loss (iRPL) has become one of the more complicated reproductive problems worldwide due to the lack of information about its etiology, which limits the counseling and treatment of patients. For that reason, iRPL requires further study of novel factors to provide scientific information for determining clinical prevention and targeted strategies. The aim of this study is to describe the most recent and promising progress in the identification of potential genetic and epigenetic risk factors for iRPL, expanding the genetic etiology of the disease.

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Authors and Affiliations

  1. School of Biological Science, Universidad Pedagógica y Tecnológica de Colombia, Avenida Central del Norte 39-115, 150003, Tunja, Boyacá, Colombia

    Luis Alejandro Arias-Sosa, Iván Darío Acosta & Maribel Forero-Castro

  2. Department of Reproductive Genetic, Fertility and Sterility Colombian Center (CECOLFES), Bogotá, Colombia

    Elkin Lucena-Quevedo, Harold Moreno-Ortiz & Clara Esteban-Pérez

Authors
  1. Luis Alejandro Arias-Sosa
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  2. Iván Darío Acosta
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  3. Elkin Lucena-Quevedo
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  4. Harold Moreno-Ortiz
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  5. Clara Esteban-Pérez
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  6. Maribel Forero-Castro
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Correspondence to Luis Alejandro Arias-Sosa.

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Arias-Sosa, L.A., Acosta, I.D., Lucena-Quevedo, E. et al. Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss. J Assist Reprod Genet 35, 355–366 (2018). https://doi.org/10.1007/s10815-017-1108-y

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  • DOI: https://doi.org/10.1007/s10815-017-1108-y

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