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Journal of Assisted Reproduction and Genetics

, Volume 35, Issue 3, pp 441–447 | Cite as

Cumulative pregnancy and live birth rates through assisted reproduction in women 44–45 years of age: is there any hope?

  • Nili Raz
  • Amir Shalev
  • Eran Horowitz
  • Ariel Weissman
  • Yossi Mizrachi
  • Hadass Ganer Herman
  • Arieh Raziel
Assisted Reproduction Technologies
  • 280 Downloads

Abstract

Purpose

The purpose of the study is to calculate the cumulative pregnancy rate and cumulative live birth rate in women undergoing in vitro fertilization (IVF) at ages 44–45.

Methods

The study calculated cumulative live pregnancy rate and cumulative live birth rate of 124 women aged 44 to 45 years old who commenced IVF treatment.

Main outcome measures

The main outcome measures are cumulative live pregnancy rate and cumulative live birth rate.

Results

Cumulative live pregnancy rates following 1, 2, 3, and 4 cycles were 5.6, 11, 17, and 20%, respectively, with no additional pregnancies in further cycles. Cumulative live birth rates following 1, 2, and 3 cycles were 1.6, 3, and 7%, respectively, with no additional live births in further cycles.

Conclusions

The cumulative pregnancy rate rises during the first 4 cycles and cumulative live birth rate rises during the first 3 cycles, with no additional rise in pregnancies or deliveries thereafter, suggesting that it is futile to offer more than 3 cycles of treatment to 44–45-year-old women.

Keywords

Assisted reproductive technology Low ovarian reserve Cumulative pregnancy rate Cumulative live birth rate 

Notes

Compliance with ethical standards

Ethical approval for this study was provided by a local Helsinki committee at Wolfson Medical Center.

References

  1. 1.
    Klipstein S, Regan M, Ryley DA, Goldman MB, Alper MM, Reindollar RH. One last chance for pregnancy: a review of 2,705 in vitro fertilization cycles initiated in women age 40 years and above. Fertil Steril. 2005;84:435–45.CrossRefPubMedGoogle Scholar
  2. 2.
    Tsafrir A, Simon A, Revel A, Reubinoff B, Lewin A, Laufer N. Retrospective analysis of 1217 IVF cycles in women aged 40 years and older. Reprod BioMed Online. 2007;14:348–55.CrossRefPubMedGoogle Scholar
  3. 3.
    Hourvitz A, Machtinger R, Maman E, Baum M, Dor J, Levron J. Assisted reproduction in women over 40 years of age: how old is too old? Reprod BioMed Online. 2009;19:599–603.CrossRefPubMedGoogle Scholar
  4. 4.
    Smith A, Tilling K, Nelson SM, Lawlor D. Live-birth rate associated with repeat in vitro fertilization treatment cycles. JAMA. 2015;314:2654–62.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Abuzeid MI, Bolonduro O, La Chance J, Abozaid T, Urich M, Ullah K, et al. Cumulative live birth rate and assisted reproduction: impact of female age and transfer day. Facts Views Vis Obgyn. 2014;6(3):145–9.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Engmann L, Maconochie N, Bekir J, Jacobs HS, Tan SL. Cumulative probability of clinical pregnancy and live birth after a multiple cycle IVF package: a more realistic assessment of overall and age-specific success rates. Br J Obstet Gynaecol. 1999;106:165–70.CrossRefPubMedGoogle Scholar
  7. 7.
    Olivius K, Friden B, Lundin K, Bergh C. Cumulative probability of live birth after three in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2002;77:505–10.CrossRefPubMedGoogle Scholar
  8. 8.
    Stern J, Brown M, Luke B, Waterman E, Lederman A, Missmer SA, et al. Calculating cumulative live-birth rates from linked cycles of assisted reproductive technology (ART): data from the Massachusetts SART CORS. Fertil Steril. 2010;94:1334–40.CrossRefPubMedGoogle Scholar
  9. 9.
    Orviet R, Bar-Hava, Yoeli R, Ashkenazi D, Rabinerson J, Bar J, et al. Results of in vitro fertilization cycles in women aged 43-45 years. Gynecol Endocrinol. 2004;18:75–8.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  1. 1.IVF Unit, Department of Obstetrics and GynecologyEdith Wolfson Medical CenterHolonIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Department of Obstetrics and GynecologyHillel Yaffe Medical CenterHaderaIsrael
  4. 4.The Ruth and Bruce Rappaport Faculty of Medicine, TechnionHaifaIsrael

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