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Cumulative pregnancy and live birth rates through assisted reproduction in women 44–45 years of age: is there any hope?

  • Assisted Reproduction Technologies
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Abstract

Purpose

The purpose of the study is to calculate the cumulative pregnancy rate and cumulative live birth rate in women undergoing in vitro fertilization (IVF) at ages 44–45.

Methods

The study calculated cumulative live pregnancy rate and cumulative live birth rate of 124 women aged 44 to 45 years old who commenced IVF treatment.

Main outcome measures

The main outcome measures are cumulative live pregnancy rate and cumulative live birth rate.

Results

Cumulative live pregnancy rates following 1, 2, 3, and 4 cycles were 5.6, 11, 17, and 20%, respectively, with no additional pregnancies in further cycles. Cumulative live birth rates following 1, 2, and 3 cycles were 1.6, 3, and 7%, respectively, with no additional live births in further cycles.

Conclusions

The cumulative pregnancy rate rises during the first 4 cycles and cumulative live birth rate rises during the first 3 cycles, with no additional rise in pregnancies or deliveries thereafter, suggesting that it is futile to offer more than 3 cycles of treatment to 44–45-year-old women.

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References

  1. Klipstein S, Regan M, Ryley DA, Goldman MB, Alper MM, Reindollar RH. One last chance for pregnancy: a review of 2,705 in vitro fertilization cycles initiated in women age 40 years and above. Fertil Steril. 2005;84:435–45.

    Article  PubMed  Google Scholar 

  2. Tsafrir A, Simon A, Revel A, Reubinoff B, Lewin A, Laufer N. Retrospective analysis of 1217 IVF cycles in women aged 40 years and older. Reprod BioMed Online. 2007;14:348–55.

    Article  CAS  PubMed  Google Scholar 

  3. Hourvitz A, Machtinger R, Maman E, Baum M, Dor J, Levron J. Assisted reproduction in women over 40 years of age: how old is too old? Reprod BioMed Online. 2009;19:599–603.

    Article  PubMed  Google Scholar 

  4. Smith A, Tilling K, Nelson SM, Lawlor D. Live-birth rate associated with repeat in vitro fertilization treatment cycles. JAMA. 2015;314:2654–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Abuzeid MI, Bolonduro O, La Chance J, Abozaid T, Urich M, Ullah K, et al. Cumulative live birth rate and assisted reproduction: impact of female age and transfer day. Facts Views Vis Obgyn. 2014;6(3):145–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Engmann L, Maconochie N, Bekir J, Jacobs HS, Tan SL. Cumulative probability of clinical pregnancy and live birth after a multiple cycle IVF package: a more realistic assessment of overall and age-specific success rates. Br J Obstet Gynaecol. 1999;106:165–70.

    Article  CAS  PubMed  Google Scholar 

  7. Olivius K, Friden B, Lundin K, Bergh C. Cumulative probability of live birth after three in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2002;77:505–10.

    Article  PubMed  Google Scholar 

  8. Stern J, Brown M, Luke B, Waterman E, Lederman A, Missmer SA, et al. Calculating cumulative live-birth rates from linked cycles of assisted reproductive technology (ART): data from the Massachusetts SART CORS. Fertil Steril. 2010;94:1334–40.

    Article  PubMed  Google Scholar 

  9. Orviet R, Bar-Hava, Yoeli R, Ashkenazi D, Rabinerson J, Bar J, et al. Results of in vitro fertilization cycles in women aged 43-45 years. Gynecol Endocrinol. 2004;18:75–8.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. IVF Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel

    Nili Raz, Amir Shalev, Eran Horowitz, Ariel Weissman, Yossi Mizrachi, Hadass Ganer Herman & Arieh Raziel

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Nili Raz, Amir Shalev, Eran Horowitz, Ariel Weissman, Yossi Mizrachi, Hadass Ganer Herman & Arieh Raziel

  3. Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel

    Nili Raz

  4. The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

    Nili Raz

Authors
  1. Nili Raz
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  2. Amir Shalev
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  3. Eran Horowitz
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  4. Ariel Weissman
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  5. Yossi Mizrachi
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  6. Hadass Ganer Herman
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  7. Arieh Raziel
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Corresponding author

Correspondence to Nili Raz.

Ethics declarations

Ethical approval for this study was provided by a local Helsinki committee at Wolfson Medical Center.

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Raz, N., Shalev, A., Horowitz, E. et al. Cumulative pregnancy and live birth rates through assisted reproduction in women 44–45 years of age: is there any hope?. J Assist Reprod Genet 35, 441–447 (2018). https://doi.org/10.1007/s10815-017-1094-0

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  • DOI: https://doi.org/10.1007/s10815-017-1094-0

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