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Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1000 cases

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study is to perform a retrospective analysis of types and frequencies of chromosomal abnormalities detected by conventional cytogenetic studies in first-trimester miscarriages after spontaneous conception and IVF.

Methods

Standard cytogenetic analysis of GTG-banded chromosomes obtained from products of conception (POCs): semi-direct and short-term cultured chorionic villi or long-term cultured fetal mesodermal cells.

Results

50.1% of first-trimester miscarriages in the studied group had chromosomal abnormalities: 59.7% of trisomies, 22% of poliploidies, 7.5% of monosomies, 7% of unbalanced structural abnormalities, and 3.8% of multiple aneuploidies. An increase in the frequency of chromosomally abnormal miscarriages was observed in the group of women above 40 when compared to groups of women under 35 (P < 0.05). No difference in frequencies and types of chromosomal abnormalities in POCs of miscarriages after ICSI and spontaneous conception was observed.

Conclusions

Approximately, 50% of first-trimester miscarriages have chromosomal abnormalities which can be detected by conventional cytogenetic analysis. The presence of chromosomal abnormality may explain the cause of miscarriage, improving the reproductive counseling and planning.

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Authors and Affiliations

  1. Clinic of Reproductive Medicine “Nadiya”, M. Kryvonosa St. 19a, Kyiv, Ukraine

    Larysa Y. Pylyp, Lyudmyla O. Spynenko, Nataliya V. Verhoglyad, Anna O. Mishenko, Dmytro O. Mykytenko & Valery D. Zukin

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  1. Larysa Y. Pylyp
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  2. Lyudmyla O. Spynenko
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  3. Nataliya V. Verhoglyad
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  4. Anna O. Mishenko
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Correspondence to Larysa Y. Pylyp.

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Pylyp, L.Y., Spynenko, L.O., Verhoglyad, N.V. et al. Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1000 cases. J Assist Reprod Genet 35, 265–271 (2018). https://doi.org/10.1007/s10815-017-1069-1

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  • DOI: https://doi.org/10.1007/s10815-017-1069-1

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