Abstract
Purpose
The purpose of this study was to examine the efficacy of an ovarian tissue transportation network for fertility preservation (FP) for cancer patients in Japan.
Methods
PubMed was searched for papers on transportation of human ovarian tissue for FP. We analyzed population, area, number of cancer patients for ovarian tissue cryopreservation (OTC), quality control/assessment and safety, cost of a cryopreservation center for the building for 30 years, and medical fees of cancer patients (operation, cryopreservation, and storage of ovarian tissue).
Results
More than twenty babies have been born in Denmark and Germany through a transportation system. Up to 400 new patients a year need OTC. The fees for removal, cryopreservation, and storage for 5 years, and transplantation of ovarian tissue are around €5,000, €4,000, and €5,000, respectively. It costs more than €5 million to establish and maintain one cryopreservation center for 30 years. If we have a few cryopreservation centers in Japan, we can cryopreserve 400 patients’ ovarian tissue per year by safer slow freezing and maintain quality control/assessment. We need to lighten the patients’ burden for easy to use FP by a government subsidy and medical insurance coverage.
Conclusions
This model has been termed the Danish model (“the woman stays - the tissue moves”). This is truly patient-centered medicine. We can have maximum effects with the minimum burden. A transportation network like those of Denmark and Germany is the best strategy for FP in Japan. It may be the best system for cancer patients, medical staff, and the Ministry of Health, Labor, and Welfare.
Similar content being viewed by others
References
Jensen AK, Macklon KT, Fedder J, Ernst E, Humaidan P, Andersen CY. 86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children. J Assist Reprod Genet. 2016; DOI:https://doi.org/10.1007/s10815-016-0843-9.
Jensen AK, Kristensen SG, Macklon KT, Jeppesen JV, Fedder J, Ernst E, et al. Outcomes of transplantations of cryopreserved ovarian tissue to 41 women in Denmark. Hum Reprod. 2015;30:2838–45.
Van der Ven H, Liebenthron J, Beckmann M, Toth B, Korell M, Krussel J, et al. Dittrich R on behalf of the FertiPROTEKT network. Ninety-five orthotopic transplantations in 74 women of ovarian tissue after cytotoxic treatment in a fertility preservation network: tissue activity, pregnancy and delivery rates. Hum Reprod. 2016;31:2031–41.
Donnez J, Dolmans MM, Demylle D, Jadoul P, Picard C, Squifflet J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405–10.
Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353:318–21.
Andersen CY, Rosendahl M, Byskov AG, Loft A, Ottosen C, Dueholm M, et al. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod. 2008;23:2266–72.
Kyono K. Fertility preservation:Transportation and cryopreservation of human ovarian tissue. 34th Annual meeting of Japan society of Fertilization and implantation. Super-hot topic2. Abstract 2016. p84.
CANCER STATISTICS IN JAPAN-2015; 82–83.
Ruddy KJ, Gelber SI, Tamimi RM, Ginsburg ES, Schapira L, Come SE, et al. Prospective study of fertility concerns and preservation strategies in young women with breast cancer. J Clin Oncol. 2014;32:1–6.
Wallace WHB, Smith AG, Kelsey TW, Edgar AE, Anderson RA. Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation. Lancet Oncol. 2014;15:1129–36.
Furui T, Takenaka M, Makino H, Terazawa K, Yamamoto A, Morishige K. An evaluation of the Gifu model in a trial for a new regional oncofertility network in Japan, focusing on its necessity and effects. Reprod Med Biol. 2016;15:107–13.
Klock SC, Zhang JX, Kazer RR. Fertility preservation for female cancer patients: early clinical experience. Fertil Steril. 2010;94:149–55.
Ben-Aharon I, Abir R, Perl G, Stein J, Gilad G, Toledano H, et al. Optimizing the process of fertility preservation in pediatric female cancer patients—a multidisciplinary program. BMC Cancer. 2016;16:620.
Sigismondi C, Papaleo E, Vigano P, Vailati S, Caniani M, Ottolina J, et al. Fertility preservation in female cancer patients: a single center experience. Chin J Cancer. 2015;34:56–60.
Lawrenz B, Jauckus J, Kupka MS, Strowitzki T, von Wolff M. Fertility preservation in >1,000 patients: patient’s characteristics, spectrum, efficacy and risks of applied preservation techniques. Arch Gynecol Obstet. 2011;283:651–6.
Nishijima C, Iwahata H, Yoshioka N, Sugishita Y, Takae S, Horage Y, Kawamura K, Suzuki N. Oncofertility care of the St. Marianna University School of Medicine Hospital. The 4th World Congress of International Society for Fertility Preservation. 2015;Abstract A-010,166.
Imberts R, Moffa F, Tsepelidis S, Simon P, Delbaere A, Devreker F, et al. Safety and useful of cryopreservation of ovarian tissue to preserve fertility: a 12-year retrospective analysis. Hum Reprod. 2014;29:1931–40.
Kyono K, Doshida M, Toya M, Sato Y, Akahira J, Sasano H. Potential indications for ovarian autotransplantation based on the analysis of 5,571 autopsy findings of females under the age of 40 in Japan. Fertil Steril. 2010;93:2429–30. [Medline] [CrossRef] CrossRef
ISFP Practice Committee, Kim SS, Donnez J, Barri P, Pellicer A, Patrizio P, et al. Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer. J Assist Reprod Genet. 2012;29:465–8.
Kataoka A, Tokunaga E, Matsuda N, Shien T, Kawabata K, Miyashita M. Clinicopathological features of young patients (<35% years of age ) with breast cancer in a Japanese Breast Cancer Society supported study. Breast Cancer 2013 Apr 16.
Kaufmann M, Hortobagyi GN, Goldhirsch A, Scholl S, Makris A, Valagussa P, et al. Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update. J Clin Oncol. 2006;24:1940–9.
Liedtke CC, Mazouni C, Hess KR, Andre F, Tordai A, Mejia JA, et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol. 2008;26:1275–81.
Kim SS, Klemp J, Fabian C. Breast cancer and fertility preservation. Fertil Steril. 2011;95:1535–43.
Dolmans MM, Luyckx V, Donnez J, Andersen CY, Greve T. Risk of transferring malignant cells with transplanted frozen-thawed ovarian tissue. Fertil Steril. 2013;99:1514–22.
Bittinger S, Nazaretian SP, Gook DA, Parmar C, Harrup RA, Stern CJ. Detection of Hodgkin lymphoma within ovarian tissue. Fertil Steril. 2011;95:803.e3–6.
von Wolff M, Montag M, Dittrich R, Denschlag D, Nawroth F, Lawrenz B. Fertility preservation in women—a practical guide to preservation techniques and therapeutic strategies in breast cancer, Hodgkin’s lymphoma and borderline ovarian tumours by the fertility preservation network FertiPROTEKT. Arch Gynecol Obstet. 2011;284:427–35.
Liebenthron J, Koster M, Drengner C, Reinsberg J, van der Ven H, Montag M. The impact of culture conditions on early follicle recruitment and growth from human ovarian cortex biopsies in vitro. Fertil Steril. 2013;100:483–491.e5.
Bastings L, Liebenthron J, Westphal JR, Beerendonk CCM, van der Ven H, Meinecke B, et al. Efficacy of ovarian tissue cryopreservation in a major European center. J Assist Reprod Genet. 2014;31:1003–12.
Meirow D, Ra’anani H, Shapira M, Brenghausen M, Chaim SD, Aviel-Ronen S, et al. Transplantations of frozen-thawed ovarian tissue demonstrate high reproductive performance and the need to revise restrictive criteria. Fertil Steril. 2016;106:467–74.
Rodriguez-Iglesias B, Novella-Maestre E, Herraiz S, Diaz-Garcia C, Pellicer N, Pellicer A. New methods to improve the safety assessment of cryopreserved ovarian tissue for fertility preservation in breast cancer patients. Fertil Steril. 2015;104:1493–1502.e2.
Schmidt KL, Ernst E, Byskov AG, Andersen AN, Andersen CY. Survival of primordial follicles following prolonged transportation of ovarian tissue prior to cryopreservation. Hum Reprod. 2003;12:2654–9.
Kyoya T, Nakamura Y, Miyatani S, Miyagawa T, Tomiyama T, Kyono K. Evaluation of oxygen consumption in human vitrified and warmed pre-antral follicles after prolonged low temperatures. ReprodMed Biol. 2014;13:47–52.
Kyono K. Fertility preservation. J Mamm Ova Res. 2013;30:101–8.
Isachenko E, Isachenko V, Nawroth F, Rahimi G, Weiss JM. Effect of long-term exposure at suprazero temperatures on activity and viability of human ovarian cortex. Fertil Steril. 2009;91:1556–9.
Isachenko V, Mallmann P, Petrunkina AM, Rahimi G, Nawroth F, Hancke K, et al. Comparison of in vitro- and chorioallantoic membrane (CAM)-culture systems for cryopreserved medulla-contained human ovarian tissue. PLoS One. 2012;7:e32549.
Isachenko V, Dittrich R, Keck G, Isachenko E, Rahimi G, van der Ven H, et al. Cryopreservation of ovarian tissue: detailed description of methods for transport, freezing and thawing. Geburtshilfe Frauenheilkd. 2012;72:927–32.
Dittrich R, Lotz L, Keck G, Hoffmann I, Mueller A, Beckmann MW, et al. Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation. Fertil Steril. 2012;97:387–90.
Muller A, Keller K, Wacker J, Dittrich R, Keck G, Montag M, et al. Retransplantation of cryopreserved ovarian tissue: the first live birth in Germany. Deutsches Arzteblatt International. 2012;109:8–13.
Rosendahl M, Schmidt KT, Ernst E, Rasmussen PE, Loft A, Byskov AG, et al. Cryopreservation of ovarian tissue for a decade in Denmark: a view of the technique. Reprod BioMed Online. 2011;22:162–71.
Kamoshita K, Okamoto N, Nakajima M, Hino T, Sugimoto K, Okamoto A, et al. Investigation of in vitro parameters and fertility of mouse ovary after storage at an optimal temperature and duration for transportation. Hum Reprod. 2016;31:774–81.
Laronda MM, Duncan FE, Hornick JE, Xu M, Pahnke JE, Whelan KA, et al. Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue. J Assist Reprod Genet. 2014;31:1013–28.
Duncan FE, Zelinski M, Gunn AH, Pahnke JE, O'Neill CL, Songsasen N, et al. Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice. Reproduction. 2016;152:R201–10.
Henry L, Fransolet M, Labied S, Blacher S, Masereel MC, Foidart JM, et al. Supplementation of transport and freezing media with anti-apoptotic drugs improves ovarian cortex survival. Journal of Ovarian Research. 2016;9:4.
Kawamura K, Cheng Y, Suzuki N, Deguchi M, Sato Y, Takae S, et al. Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc Natl Acad Sci U S A. 2013;110:17474–9.
Kagawa N, Silber S, Kuwayama M. Successful vitrification of bovine and human ovarian tissue. RBM Online. 2009;18:568–77.
Hashimoto S, Suzuki N, Yamanaka M, Hosoi Y, Ishizuka B, Morimoto Y. Effects of vitrification solutions and equilibration times on the morphology of cynomolgus ovarian tissues. Reprod BioMed Online. 2010;21:501–9.
Obata R, Nakamura Y, Okuyama N, Sasaki C, Ogura Y, Aono N, Hamano S, Hashimoto T, Kyono K. Comparison of residual dimethyl sulfoxide (DMSO) and ethylene glycol (EG) concentration in bovine ovarian tissue during warming steps between slow freezing and vitrification methods. 2017;P-513, The 33rd Meeting of the ESHRE.
Nakamura Y, Obata R, Okuyama N, Aono N, Hashimoto T, Kyono K. Residual ethylene glycol (EG) and dimethyl sulfoxide (DMSO) concentration in ovarian tissue during warming steps of vitrification protocol. Reprod Biomed Online. Online publication complete: 20-JUN-2017. DOI: https://doi.org/10.1016/j.rbmo.2017.05.016.
Iwatani M, Ikegami K, Kremenska Y, Hattori N, Tanaka S, Yagi S, et al. Dimethyl sulfoxide has an impact on epigenetic profile in mouse embryoid body. Stem Cells. 2006;24:2549–56.
Larman MG, Katz-Jaffe MG, McCallie B, Filipovits JA, Gardner DK. Analysis of global gene expression following mouse blastocyst cryopreservation. Hum Reprod. 2011;26:2672–80.
Cordeiro RM, Stirling S, Fahy GM, de Magalhaes JP. Insights on cryoprotectant toxicity from gene expression profiling of endothelial cells exposed to ethylene glycol. Cryobiology. 2015;71:405–12.
Dolmans MM, Jadoul P, Gilliaux S, Amorim CA, Luyckx V, Squifflet J, et al. A review of 15 years of ovarian tissue bank activities. J Assist Reprod Genet. 2013;30:305–14.
Brigham KB, Cadier B, Chevreul K. The diversity of regulation and public financing of IVF in Europe and its impact on utilization. Hum Reprod. 2013;28:666–75.
Directive 2011/24 EU of the European Parliament and of the Council of 9 March 2011 on the application of patents’ rights in cross-border healthcare.European Court of Human Rights. Case of S.H. and others v. Austria, 2011. http://cmiskp.echr.coe.int/tkp197/view.asp?action=html&documentld=894729portal=hbkm&source=extemalbydocnumber&table=F69A27FD8FB86142BF01c1166DEA398649. (26 November 2012, date last accessed).
Shenfeld F, de Mouzon J, Pennings G, Ferraretti AP, Nyboe Andersen A, de Wert G, et al. The ESHRE taskforce on cross border reproductive care. Cross border reproductive care in six European countries. Hum Reprod. 2010;25:1361–8.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kyono, K., Hashimoto, T., Toya, M. et al. A transportation network for human ovarian tissue is indispensable to success for fertility preservation. J Assist Reprod Genet 34, 1469–1474 (2017). https://doi.org/10.1007/s10815-017-1022-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10815-017-1022-3