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Journal of Assisted Reproduction and Genetics

, Volume 34, Issue 11, pp 1553–1557 | Cite as

Egg donation of vitrified oocytes bank produces similar pregnancy rates by blastocyst transfer when compared to fresh cycle

  • Thais S. DominguesEmail author
  • Ana Paula Aquino
  • Bruna Barros
  • Raquel Mazetto
  • Mariana Nicolielo
  • Carolina M. Kimati
  • Talita Devecchi
  • Tatiana C. S. Bonetti
  • Paulo C. Serafini
  • Eduardo L. A. Motta
Assisted Reproduction Technologies

Abstract

Purpose

Advances in reproductive techniques, mainly the introduction of oocyte vitrification, have provided the opportunity to conceive from oocyte banks. The aim of this study was to compare the clinical outcomes of fresh and vitrified oocytes in an egg donation program following blastocyst transfer.

Methods

This retrospective observational study included 504 oocyte donation cycles. All donor women were younger than 30 years of age. The recipient cycles were divided into two groups: fresh oocytes (n = 78) or vitrified oocytes (n = 426). All oocytes were fertilized by ICSI using ejaculated sperm, followed by blastocyst transfer. Endometrium preparation was performed with estradiol valerate plus micronized progesterone according to standard protocols.

Results

Recipients were of similar age (fresh 42.0 ± 4.5 years vs vitrified 41.8 ± 4.8 years; p = 0.790). The fresh group received more mature oocytes for injection compared to the vitrified group (10.1 ± 2.8 vs 9.2 ± 2.2; p = 0.005). The two pronuclei (2PN) rate (74.5 vs 77.4%; p = 0.195) and blastocyst rate (48.8 vs 51.6%; 0.329) were similar between the fresh and vitrified groups, respectively. The rates of clinical pregnancy were 60.9% in the fresh and 59.0% in the vitrified groups (p = 0.771).

Conclusions

Our findings suggest that vitrified oocytes result in similar pregnancy rates when compared to fresh oocytes with blastocyst transfer in an egg donation program. Moreover, vitrified oocytes may allow for a better cycle schedule, starting with a lower number of oocytes to be fertilized. Therefore, we hypothesize that egg banks with vitrified oocytes could be safely utilized in an egg donation program.

Keywords

Oocyte donation Oocyte vitrification In vitro fertilization Blastocyst transfer Pregnancy rates 

Notes

Acknowledgements

The authors gratefully acknowledge the contributions of the team from Huntington Reproductive Medicine, São Paulo, Brazil, for excellent support with patients and procedures.

References

  1. 1.
    Chen C. Pregnancy after human oocyte cryopreservation. Lancet. 1986;1:884–6.CrossRefPubMedGoogle Scholar
  2. 2.
    Practice Committees of American Society for Reproductive Medicine; Society for Assisted Reproductive. Mature oocyte cryopreservation: a guideline. Fertil Steril. 2013;99:37–43.Google Scholar
  3. 3.
    Ubaldi F, Anniballo R, Romano S, Baroni E, Albricci L, Colamaria S, et al. Cumulative ongoing pregnancy rate achieved with oocyte vitrification and cleavage stage transfer without embryo selection in a standard infertility program. Hum Reprod. 2010;25:1199–205.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Rienzi L, Romano S, Albricci L, Maggiulli R, Capalbo A, Baroni E, et al. Embryo development of fresh ‘versus’ vitrified metaphase II oocytes after ICSI: a prospective randomized sibling-oocyte study. Hum Reprod. 2010;25:66–73.CrossRefPubMedGoogle Scholar
  5. 5.
    De Munck N, Belva F, Van de Velde H, Verheyen G, Stoop D. Closed oocyte vitrification and storage in an oocyte donation programme: obstetric and neonatal outcome. Hum Reprod. 2016;31(5):1024–33.CrossRefPubMedGoogle Scholar
  6. 6.
    Cobo A, Serra V, Garrido N, Olmo I, Pellicer A, Remohi J. Obstetric and perinatal outcome of babies born from vitrified oocytes. Fertil Steril. 2014;102:1006–15. e4CrossRefPubMedGoogle Scholar
  7. 7.
    Cobo A, Kuwayama M, Perez S, Ruiz A, Pellicer A, Remohi J. Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method. Fertil Steril. 2008;89:1657–64.CrossRefPubMedGoogle Scholar
  8. 8.
    Grifo JA, Noyes N. Delivery rate using cryopreserved oocytes is comparable to conventional in vitro fertilization using fresh oocytes: potential fertility preservation for female cancer patients. Fertil Steril. 2010;93:391–6.CrossRefPubMedGoogle Scholar
  9. 9.
    Nagy ZP, Chang CC, Shapiro DB, Bernal DP, Elsner CW, Mitchell-Leef D, et al. Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking. Fertil Steril. 2009;92:520–6.CrossRefPubMedGoogle Scholar
  10. 10.
    Cobo A, Meseguer M, Remohi J, Pellicer A. Use of cryo-banked oocytes in an ovum donation programme: a prospective, randomized, controlled, clinical trial. Hum Reprod. 2010;25:2239–46.CrossRefPubMedGoogle Scholar
  11. 11.
    Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet. 1992;340:17–8.CrossRefPubMedGoogle Scholar
  12. 12.
    Chian RC, Huang JY, Tan SL, Lucena E, Saa A, Rojas A, et al. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reprod BioMed Online. 2008;16:608–10.CrossRefPubMedGoogle Scholar
  13. 13.
    Noyes N, Porcu E, Borini A. Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod BioMed Online. 2009;18:769–76.CrossRefPubMedGoogle Scholar
  14. 14.
    Kushnir VA, Barad DH, Albertini DF, Darmon SK, Gleicher N. Outcomes of fresh and cryopreserved oocyte donation. JAMA. 2015;314:623–4.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Thais S. Domingues
    • 1
    • 2
    Email author
  • Ana Paula Aquino
    • 1
  • Bruna Barros
    • 1
  • Raquel Mazetto
    • 1
  • Mariana Nicolielo
    • 1
  • Carolina M. Kimati
    • 1
  • Talita Devecchi
    • 1
  • Tatiana C. S. Bonetti
    • 1
    • 2
  • Paulo C. Serafini
    • 1
    • 3
  • Eduardo L. A. Motta
    • 1
    • 2
  1. 1.Huntington - Medicina ReprodutivaSao PauloBrazil
  2. 2.Disciplina de Ginecologia Endocrinológica, Departamento de GinecologiaEscola Paulista de Medicina da Universidade Federal de Sao Paulo (UNIFESP-EPM)Sao PauloBrazil
  3. 3.Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de MedicinaUniversidade de Sao Paulo (USP)Sao PauloBrazil

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