Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS
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The pro-inflammatory advanced glycation end products (AGEs) and their anti-inflammatory soluble receptors, sRAGE, play a role in the pathogenesis of PCOS. There is a correlation between vitamin D (vit D) and sRAGE in the serum, whereby vit D replacement increases serum sRAGE levels in women with PCOS, thus incurring a protective anti-inflammatory role.
This study aims to compare levels of sRAGE, N-carboxymethyl-lysine (CML; one of the AGEs), and 25-hydroxy-vit D in the follicular fluid (FF) of women with or without PCOS, and to evaluate the correlation between sRAGE and 25-hydroxy-vit D in the FF.
Material and methods
Women with (n = 12) or without (n = 13) PCOS who underwent IVF were prospectively enrolled.
Women with PCOS had significantly higher anti-Mullerian hormone levels, higher number of total retrieved and mature oocytes, and higher number of day 3 and day 5 embryos formed. Compared to women without PCOS, women with PCOS had significantly lower FF sRAGE levels. In women with PCOS, in women without PCOS, and in all participants together, there was a significant positive correlation between sRAGE and 25-hydroxy-vit D. sRAGE positively correlated with CML in women without PCOS but not in women with PCOS.
In women with PCOS, the low ovarian levels of the anti-inflammatory sRAGE suggest that sRAGE could represent a biomarker and a potential therapeutic target for ovarian dysfunction in PCOS. Whether there is a direct causal relationship between sRAGE and vit D in the ovaries remains to be determined.
KeywordsPCOS Advanced glycation end products RAGE sRAGE Vitamin D
Advanced glycation end products
Soluble receptor for advanced glycation end products
We would like to thank Dr. Bharati Kalgi M.D., Grace Woo, and Dr. Rosine Rosanel M.D. in helping us collect the specimens for the study.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Grant from Ferring Pharmaceuticals Inc. to Z.M and grant from Genesis Foundation to D.G.
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