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Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS

  • Reproductive Physiology and Disease
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The pro-inflammatory advanced glycation end products (AGEs) and their anti-inflammatory soluble receptors, sRAGE, play a role in the pathogenesis of PCOS. There is a correlation between vitamin D (vit D) and sRAGE in the serum, whereby vit D replacement increases serum sRAGE levels in women with PCOS, thus incurring a protective anti-inflammatory role.

Objective

This study aims to compare levels of sRAGE, N-carboxymethyl-lysine (CML; one of the AGEs), and 25-hydroxy-vit D in the follicular fluid (FF) of women with or without PCOS, and to evaluate the correlation between sRAGE and 25-hydroxy-vit D in the FF.

Material and methods

Women with (n = 12) or without (n = 13) PCOS who underwent IVF were prospectively enrolled.

Results

Women with PCOS had significantly higher anti-Mullerian hormone levels, higher number of total retrieved and mature oocytes, and higher number of day 3 and day 5 embryos formed. Compared to women without PCOS, women with PCOS had significantly lower FF sRAGE levels. In women with PCOS, in women without PCOS, and in all participants together, there was a significant positive correlation between sRAGE and 25-hydroxy-vit D. sRAGE positively correlated with CML in women without PCOS but not in women with PCOS.

Conclusions

In women with PCOS, the low ovarian levels of the anti-inflammatory sRAGE suggest that sRAGE could represent a biomarker and a potential therapeutic target for ovarian dysfunction in PCOS. Whether there is a direct causal relationship between sRAGE and vit D in the ovaries remains to be determined.

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Abbreviations

AGEs:

Advanced glycation end products

sRAGE:

Soluble receptor for advanced glycation end products

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Acknowledgements

We would like to thank Dr. Bharati Kalgi M.D., Grace Woo, and Dr. Rosine Rosanel M.D. in helping us collect the specimens for the study.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY, 11219, USA

    Deepika Garg & Richard Grazi

  2. Departments of Pathology and Obstetrics and Gynecology, Women and Infants Hospital, Alpert, Medical School at Brown University, Providence, RI, USA

    Geralyn M. Lambert-Messerlian

  3. Department of Obstetrics and Gynecology, NYU School of Medicine, New York, NY, 11014, USA

    Zaher Merhi

Authors
  1. Deepika Garg
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  2. Richard Grazi
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  3. Geralyn M. Lambert-Messerlian
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  4. Zaher Merhi
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Corresponding author

Correspondence to Deepika Garg.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Funding

Grant from Ferring Pharmaceuticals Inc. to Z.M and grant from Genesis Foundation to D.G.

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Garg, D., Grazi, R., Lambert-Messerlian, G.M. et al. Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS. J Assist Reprod Genet 34, 1507–1513 (2017). https://doi.org/10.1007/s10815-017-1011-6

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  • DOI: https://doi.org/10.1007/s10815-017-1011-6

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