Journal of Assisted Reproduction and Genetics

, Volume 34, Issue 11, pp 1501–1506 | Cite as

Chemokine (C-C motif) ligand-2 (CCL2) and oxidative stress markers in recurrent pregnancy loss and repeated implantation failure

  • Müberra Namlı KalemEmail author
  • Nilufer Akgun
  • Ziya Kalem
  • Batuhan Bakirarar
  • Tugrul Celik
Reproductive Physiology and Disease



The main purpose of this study is to evaluate the inflammatory response and oxidative stress together in the cases of recurrent pregnancy loss (RPL) and repeated implantation failure (RIF).


This is a cross-sectional study conducted to compare infertile patients who have RIF and patients with RPL histories in terms of CCL2, TAS, TOS, and OSI. To this end, two study groups were formed by primary-infertile women with RIF history and women with nulliparous RPL history who consulted a university hospital between 2014 and 2016, and a control group was formed by multiparous women who had no pregnancy loss. With 30 women in each group, 90 women in total were included in the study. CCL2, TAS, and TOS blood levels were measured and oxidative stress index was calculated in all participants.


The patients with RPL and RIF had higher levels of CCL2 than those in the control group. The TOS, TAS, and OSI levels did not differ in RPL and RIF groups from the control group. No statistically significant relationship was found between CCL2 and the TOS, TAS, and OSI values.


Oxidative stress markers in the pregestational period did not have a predictive value in the RPL and RIF. CCL2 might be useful in risk prediction.


CCL2 Oxidative stress index Recurrent implantation failure Recurrent pregnancy loss 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyLiv Hospital AnkaraAnkaraTurkey
  2. 2.Department of Obstetrics and GynecologyAmerican HospitalIstanbulTurkey
  3. 3.Gurgan Clinic, IVF and Women Health Center, Department of IVFAnkaraTurkey
  4. 4.Department of BiostatisticAnkara UniversityAnkaraTurkey
  5. 5.Department of BiochemistryCankaya HospitalAnkaraTurkey

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