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What is the best predictor of severe ovarian hyperstimulation syndrome in IVF? A cohort study

  • Assisted Reproduction Technologies
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Abstract

Purpose

The purpose of the present study is to study what is the best predictor of severe ovarian hyperstimulation syndrome (OHSS) in IVF.

Methods

This is a retrospective analysis of all consecutive IVF/intracytoplasmic injection cycles performed during a 5-year period (2009–2014) in a single university fertility centre. All fresh IVF cycles where ovarian stimulation was performed with gonadotrophins and GnRH agonists or antagonists and triggering of final oocyte maturation was induced with the administration of urinary or recombinant hCG were analyzed (2982 patients undergoing 5493 cycles). Because some patients contributed more than one cycle, the analysis of the data was performed with the use of generalized estimating equation (GEE).

Results

Severe OHSS was diagnosed in 20 cycles (0.36%, 95% CI 0.20–0.52). The number of follicles ≥10 mm on the day of triggering final oocyte maturation represents the best predictor of severe OHSS in IVF cycles. The cutoff in the number of follicles ≥10 mm with the best capacity to discriminate between women that will and will not develop severe OHSS was ≥15.

Conclusion

The presence of more than 15 follicles ≥10 mm on the day of triggering final oocyte maturation represents the best predictor of severe OHSS in IVF cycles.

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Authors and Affiliations

  1. Fertility Clinic, Department of Obstetrics and Gynecology, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium

    Theoni B Tarlatzi, Fabienne Devreker, Yvon Englert & Anne Delbaere

  2. Women’s and Children’s Health, St George Hospital, University of New South Wales, Sydney, NSW, Australia

    Christos A Venetis

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  1. Theoni B Tarlatzi
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  2. Christos A Venetis
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Correspondence to Theoni B Tarlatzi.

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The authors declare that they have no conflict of interest.

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This study was approved by the Institutional Review Board (P2014/210).

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Tarlatzi, T.B., Venetis, C.A., Devreker, F. et al. What is the best predictor of severe ovarian hyperstimulation syndrome in IVF? A cohort study. J Assist Reprod Genet 34, 1341–1351 (2017). https://doi.org/10.1007/s10815-017-0990-7

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  • DOI: https://doi.org/10.1007/s10815-017-0990-7

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