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Journal of Assisted Reproduction and Genetics

, Volume 34, Issue 2, pp 201–207 | Cite as

Obstetric and perinatal outcome of babies born from sperm selected by MACS from a randomized controlled trial

  • Laura Romany
  • Nicolas Garrido
  • Ana Cobo
  • Belen Aparicio-Ruiz
  • Vicente Serra
  • Marcos MeseguerEmail author
Assisted Reproduction Technologies

Abstract

Purpose

The purpose of this study is to assess outcomes after magnetic-activated cell sorting (MACS) technology on obstetric and perinatal outcomes compared with those achieved after swim up from randomized controlled trial.

Methods

This is a two-arm, unicentric, prospective, randomized, and triple-blinded trial and has a total of 237 infertile couples, between October 2010 and January 2013. A total of 65 and 66 newborns from MACS and control group, respectively, were described.

Results

MACS had no clinically relevant adverse effects on obstetric and perinatal outcomes. No differences were found for obstetric problems including premature rupture of membranes 6.1% (CI95% 0–12.8) vs. 5.9% (CI95% 0–12.4), 1st trimester bleeding 28.6% (CI95% 15.9–41.2) vs. 23.5% (CI95% 11.9–35.1), invasive procedures as amniocentesis 2.0% (CI95% 0–5.9) vs. 3.9% (CI95% 0–9.2), diabetes 14.3% (CI95% 4.5–24.1) vs. 9.8% (CI95% 1.6–17.9), anemia 6.1% (CI95% 0–12.8) vs. 5.9%(CI95% 0–12.4), 2nd and 3rd trimesters 10.2% (CI95% 1.7–18.7) vs. 5.9% (CI95% 0–12.4), urinary tract infection 8.2% (CI95% 0.5–15.9) vs. 3.9% (CI95% 0–9.2), pregnancy-induced hypertension 6.1% (CI95% 0–12.8) vs. 15.7% (CI95% 5.7–25.7), birth weight (g) 2684.10 (CI95% 2499.48–2868.72) vs. 2676.12 (CI95% 2499.02–2852.21), neonatal height (cm) 48.3 (CI95% 47.1–49.4) vs. 46.5 (CI95% 44.6–48.4), and gestational cholestasis 0%(CI95% 0–0) vs. 3.9% (CI95% 0–9.2), respectively, in MACS group compared with control group.

Conclusions

Our data suggest that MACS technology does not increase or decrease Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation adverse obstetric and perinatal outcomes in children conceived when this technology was performed, being the largest randomized control trial with live birth reported results with MACS.

Keywords

Ovum donation program MACS technology Sperm selection Perinatal outcome Obstetrics 

Notes

Compliance with ethical standards

The study was approved by the Institutional Review Board of the Instituto Valenciano de Infertilidad, Valencia, Spain (0810-C-051-MM).

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Laura Romany
    • 1
  • Nicolas Garrido
    • 1
  • Ana Cobo
    • 1
  • Belen Aparicio-Ruiz
    • 1
  • Vicente Serra
    • 1
  • Marcos Meseguer
    • 1
    • 2
    Email author
  1. 1.Instituto Valenciano de InfertilidadUniversidad de ValenciaValenciaSpain
  2. 2.Instituto Valenciano de InfertilidadValenciaSpain

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