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Obstetric and perinatal outcome of babies born from sperm selected by MACS from a randomized controlled trial

  • Assisted Reproduction Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study is to assess outcomes after magnetic-activated cell sorting (MACS) technology on obstetric and perinatal outcomes compared with those achieved after swim up from randomized controlled trial.

Methods

This is a two-arm, unicentric, prospective, randomized, and triple-blinded trial and has a total of 237 infertile couples, between October 2010 and January 2013. A total of 65 and 66 newborns from MACS and control group, respectively, were described.

Results

MACS had no clinically relevant adverse effects on obstetric and perinatal outcomes. No differences were found for obstetric problems including premature rupture of membranes 6.1% (CI95% 0–12.8) vs. 5.9% (CI95% 0–12.4), 1st trimester bleeding 28.6% (CI95% 15.9–41.2) vs. 23.5% (CI95% 11.9–35.1), invasive procedures as amniocentesis 2.0% (CI95% 0–5.9) vs. 3.9% (CI95% 0–9.2), diabetes 14.3% (CI95% 4.5–24.1) vs. 9.8% (CI95% 1.6–17.9), anemia 6.1% (CI95% 0–12.8) vs. 5.9%(CI95% 0–12.4), 2nd and 3rd trimesters 10.2% (CI95% 1.7–18.7) vs. 5.9% (CI95% 0–12.4), urinary tract infection 8.2% (CI95% 0.5–15.9) vs. 3.9% (CI95% 0–9.2), pregnancy-induced hypertension 6.1% (CI95% 0–12.8) vs. 15.7% (CI95% 5.7–25.7), birth weight (g) 2684.10 (CI95% 2499.48–2868.72) vs. 2676.12 (CI95% 2499.02–2852.21), neonatal height (cm) 48.3 (CI95% 47.1–49.4) vs. 46.5 (CI95% 44.6–48.4), and gestational cholestasis 0%(CI95% 0–0) vs. 3.9% (CI95% 0–9.2), respectively, in MACS group compared with control group.

Conclusions

Our data suggest that MACS technology does not increase or decrease Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation adverse obstetric and perinatal outcomes in children conceived when this technology was performed, being the largest randomized control trial with live birth reported results with MACS.

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Author information

Authors and Affiliations

  1. Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain

    Laura Romany, Nicolas Garrido, Ana Cobo, Belen Aparicio-Ruiz, Vicente Serra & Marcos Meseguer

  2. Instituto Valenciano de Infertilidad, Plaza de la Policía Local, 3, Valencia, 46015, Spain

    Marcos Meseguer

Authors
  1. Laura Romany
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  2. Nicolas Garrido
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  3. Ana Cobo
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  4. Belen Aparicio-Ruiz
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  5. Vicente Serra
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  6. Marcos Meseguer
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Corresponding author

Correspondence to Marcos Meseguer.

Ethics declarations

The study was approved by the Institutional Review Board of the Instituto Valenciano de Infertilidad, Valencia, Spain (0810-C-051-MM).

Additional information

Capsule IVF cycles where sperm has been prepared by magnetic activated cell sorting show no differences in obstetric and perinatal outocomes compared to standard sperm preparation.

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Romany, L., Garrido, N., Cobo, A. et al. Obstetric and perinatal outcome of babies born from sperm selected by MACS from a randomized controlled trial. J Assist Reprod Genet 34, 201–207 (2017). https://doi.org/10.1007/s10815-016-0838-6

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  • DOI: https://doi.org/10.1007/s10815-016-0838-6

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