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The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles

  • Genetics
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Abstract

Purpose

The objective of this study was the elucidation of the possible role of the single-nucleotide polymorphisms (SNP) at position -29 and 2039 of the FSH receptor gene (FSHR) as independent predictive markers of ovarian response. Indeed, the tailoring of reproductive treatments is crucial for both maximizing the success of IVF patients and obtaining a reduction in hypo- or hyper-response rates.

Methods

This prospective, observational study analyzed the association of -29 and 2039 FSHR polymorphisms with the number of retrieved oocytes in 140 patients attending an IVF/ICSI cycle for severe male factors (≤5,000,000 spermatozoa/mL) or tubal factors at the ANDROS Day Surgery Clinic, Palermo, Italy.

Results

The results of this study demonstrate that the genetic combination of A/G for polymorphism c.2039 A>G with G/G for polymorphism c.-29 G>A is significantly associated with the highest number of collected oocytes (p = 0.03). This association was significant even after controlling for the effect of other clinical variables.

Conclusions

The A/G-G/G allelic variant, identified as an independent variable, if confirmed in a larger number of patients, could be considered as a new genetic biomarker, which could increase the efficacy of prediction models for ovarian stimulation.

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Author information

Authors and Affiliations

  1. Reproductive Medicine Unit, ANDROS Day Surgery Clinic, Via Ausonia 43/45, 90144, Palermo, Italy

    Adolfo Allegra, Angelo Marino, Piero Scaglione & Aldo Volpes

  2. Dipartimento di Biopatologia e Biotecnologie Mediche, Università di Palermo, Palermo, Italy

    Stefania Raimondo & Riccardo Alessandro

  3. Unità Operativa Complessa di Ginecologia ed Ostetricia, A.R.N.A.S. Ospedale Civico, Palermo, Italy

    Antonio Maiorana

  4. Medical Statistics Unit, ANDROS Day Surgery Clinic, Palermo, Italy

    Salvatore Gullo

Authors
  1. Adolfo Allegra
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  2. Angelo Marino
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  3. Stefania Raimondo
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  4. Antonio Maiorana
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  6. Piero Scaglione
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  7. Aldo Volpes
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Corresponding author

Correspondence to Adolfo Allegra.

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The authors declare that they have no conflict of interest.

Funding

This research did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector; the funds were provided directly by Centro Andros S.r.l., Palermo, Italy.

Additional information

Capsule The genetic variant A/G-G/G is an independent predictor of the number of retrieved oocytes in IVF/ICSI cycles.

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Allegra, A., Marino, A., Raimondo, S. et al. The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles. J Assist Reprod Genet 34, 263–273 (2017). https://doi.org/10.1007/s10815-016-0835-9

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