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Journal of Assisted Reproduction and Genetics

, Volume 34, Issue 2, pp 263–273 | Cite as

The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles

  • Adolfo AllegraEmail author
  • Angelo Marino
  • Stefania Raimondo
  • Antonio Maiorana
  • Salvatore Gullo
  • Piero Scaglione
  • Aldo Volpes
  • Riccardo Alessandro
Genetics

Abstract

Purpose

The objective of this study was the elucidation of the possible role of the single-nucleotide polymorphisms (SNP) at position -29 and 2039 of the FSH receptor gene (FSHR) as independent predictive markers of ovarian response. Indeed, the tailoring of reproductive treatments is crucial for both maximizing the success of IVF patients and obtaining a reduction in hypo- or hyper-response rates.

Methods

This prospective, observational study analyzed the association of -29 and 2039 FSHR polymorphisms with the number of retrieved oocytes in 140 patients attending an IVF/ICSI cycle for severe male factors (≤5,000,000 spermatozoa/mL) or tubal factors at the ANDROS Day Surgery Clinic, Palermo, Italy.

Results

The results of this study demonstrate that the genetic combination of A/G for polymorphism c.2039 A>G with G/G for polymorphism c.-29 G>A is significantly associated with the highest number of collected oocytes (p = 0.03). This association was significant even after controlling for the effect of other clinical variables.

Conclusions

The A/G-G/G allelic variant, identified as an independent variable, if confirmed in a larger number of patients, could be considered as a new genetic biomarker, which could increase the efficacy of prediction models for ovarian stimulation.

Keywords

FSH receptor polymorphisms Treatment personalization COH IVF/ICSI 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Funding

This research did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector; the funds were provided directly by Centro Andros S.r.l., Palermo, Italy.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Adolfo Allegra
    • 1
    Email author
  • Angelo Marino
    • 1
  • Stefania Raimondo
    • 2
  • Antonio Maiorana
    • 3
  • Salvatore Gullo
    • 4
  • Piero Scaglione
    • 1
  • Aldo Volpes
    • 1
  • Riccardo Alessandro
    • 2
  1. 1.Reproductive Medicine UnitANDROS Day Surgery ClinicPalermoItaly
  2. 2.Dipartimento di Biopatologia e Biotecnologie MedicheUniversità di PalermoPalermoItaly
  3. 3.Unità Operativa Complessa di Ginecologia ed OstetriciaA.R.N.A.S. Ospedale CivicoPalermoItaly
  4. 4.Medical Statistics UnitANDROS Day Surgery ClinicPalermoItaly

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