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Effect of body mass index on the outcomes of controlled ovarian hyperstimulation in Chinese women with polycystic ovary syndrome: a multicenter, prospective, observational study

  • Assisted Reproduction Technologies
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Abstract

Purpose

The purpose of the present study is to explore the influence of body mass index (BMI) on outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) techniques in Chinese women with polycystic ovary syndrome (PCOS).

Methods

This was a multicenter, prospective, observational study that enrolled 800 subjects with PCOS from nine hospitals in China. Patients were categorized according to BMI categories: underweight, <18.5 kg/m2; normal, 19–23.9 kg/m2; overweight, 24–27.9 kg/m2; and obese, ≥28 kg/m2. Total recombinant follicle-stimulating hormone (rFSH) dose used, estradiol, and progesterone levels on human chorionic gonadotropin (hCG) day; implantation rate; and biochemical, clinical, and ongoing pregnancy rates were compared among BMI categories. Hormone levels (estradiol, follicle-stimulating hormone (FSH), LH, testosterone, and progesterone) were measured using electrochemiluminescence assays.

Results

Among the 774 subjects, 27.3 % were overweight and 8.1 % were obese. The rFSH dose used differed significantly among BMI categories (P < 0.001). The implantation rate was lower in obese subjects than that in normal-weight subjects (25.3 vs 45.7 %). Clinical pregnancy rate per transfer differed among BMI categories (P = 0.033), but there was no difference for biochemical (P = 0.327) and ongoing (P = 0.084) pregnancy rates. The miscarriage rate was similar among BMI categories.

Conclusions

More than one third of Chinese women with PCOS undergoing IVF/ICSI are overweight or obese. Elevated BMI is associated with reduced clinical pregnancy rate but similar ongoing pregnancy rates, suggesting that BMI has little impact on IVF outcomes.

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Acknowledgments

This study was supported by Merck Serono Co., Ltd. (Grant number EMR700623-530). We thank Wenfeng Chen (principal biostatistician) from Global Biostatistics & Epidemiology, Merck Serono (Beijing) Pharmaceutical R&D Co., Ltd. In addition, we thank all the staffs from research centers for their assistance.

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Authors and Affiliations

  1. Center for Reproductive Medicine, Shandong University, Jinan, China

    Yan Sheng & Zijiang Chen

  2. Reproductive & Genetic Hospital CITIC-Xiangya, Changsha, China

    Guangxiu Lu

  3. Jiangsu Province Hospital, Nanjing, China

    Jiayin Liu

  4. The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

    Xiaoyan Liang

  5. The First People’s Hospital of Yunnan Province, Kunming, China

    Yanping Ma

  6. The First Hospital of Lanzhou University, Lanzhou, China

    Xuehong Zhang

  7. Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    Songying Zhang

  8. The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Yingpu Sun

  9. Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Yun Sun

  10. Merck Serono Co., Ltd, Beijing, China

    Wenfeng Chen & Wenhui Fang

Authors
  1. Yan Sheng
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  2. Guangxiu Lu
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  3. Jiayin Liu
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  5. Yanping Ma
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  9. Yun Sun
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  10. Wenfeng Chen
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  11. Wenhui Fang
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  12. Zijiang Chen
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Corresponding author

Correspondence to Zijiang Chen.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the ethics committees of the participating hospitals.

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All study subjects were fully informed as to the nature of the study and provided written consent for inclusion.

Additional information

Capsule Elevated body mass index is associated with reduced clinical pregnancy rate but similar ongoing pregnancy rates.

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Sheng, Y., Lu, G., Liu, J. et al. Effect of body mass index on the outcomes of controlled ovarian hyperstimulation in Chinese women with polycystic ovary syndrome: a multicenter, prospective, observational study. J Assist Reprod Genet 34, 61–70 (2017). https://doi.org/10.1007/s10815-016-0830-1

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