Abstract
Purpose
This study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women.
Methods
We genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms.
Results
No significant difference was observed in genotypic frequency between control and endometriosis groups for G634C and K469E polymorphisms (p = 0.61 and p = 0.22, respectively). In addition, no significant difference between stages I-II and III-IV of the disease was found for both SNPs (p = 0.63 and p = 0.24, respectively). All individuals were wild homozygotes for G241R polymorphism.
Conclusion
This study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.
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This study was supported by HC-LIM/FMUSP (LIM-40).
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This study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.
Nathalie Zamagni Bessa and Daniela de Oliveira Francisco contributed equally to this work.
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Bessa, N.Z., Francisco, D.d.O., Andres, M.d.P. et al. Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women. J Assist Reprod Genet 33, 1487–1492 (2016). https://doi.org/10.1007/s10815-016-0796-z
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DOI: https://doi.org/10.1007/s10815-016-0796-z