Journal of Assisted Reproduction and Genetics

, Volume 33, Issue 11, pp 1481–1486 | Cite as

The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population




Chromosomal polymorphisms (CPs) have been reported to be associated with infertility; however, their effects on the outcomes of in vitro fertilization/intracytoplasmic sperm injection–embryo transfer (IVF/ICSI–ET) are still controversial. In this retrospective study, we aimed to evaluate the effect of CPs on IVF/ICSI–ET outcomes.


To investigate whether CPs affected the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population, we evaluated infertile couples with male carriers of CPs (n = 348), infertile couples with female carriers (n = 99), and unaffected couples (n = 400) who had received their first treatment cycles in our hospital between January 2013 and March 2015.


CPs in either male or female carriers seemed to have adverse effects on IVF/ICSI–ET outcomes. CPs in male carriers affected outcomes mainly by decreasing the rates of fertilization, embryo cleavage, good quality embryos, clinical pregnancies, ongoing pregnancies, and deliveries as well as increasing the biochemical pregnancy rate (P < 0.05); CPs in female carriers affected outcomes only by lowering the embryo cleavage rate (P < 0.05). The mean fertilization rate of couples with male CP carriers undergoing IVF was significantly lower than that in those undergoing ICSI (61.1 versus 66.5 %, respectively; P = 0.0004).


Our data provide evidence for the involvement of CPs in the poor outcomes of fresh IVF/ICSI–ET cycles in a Chinese population. The use of ICSI might improve outcomes by increasing the fertilization rate for men with CPs.


Chromosomal polymorphisms Clinical outcomes IVF/ICSI cycles Fertilization rate Cleavage rate 



We thank the patients and their families for agreeing to participate in this study and colleagues whose participation made this project possible. We also thank Jinzhu Zhao, Bo Deng, and Lanlan Liang for establishing the patient archives and Lanying Li for the patient follow-up. We appreciated the help and advice of our colleagues. This study was supported by the National Natural Science Foundation of China (grant numbers 313010232 and 81401261).

Compliance with ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the ethics committee of the Reproductive Medicine Hospital of the First Hospital of Lanzhou University and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent of the ethics committee was not required.

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.


This study was supported by the National Natural Science Foundation of People’s Republic of China (grant numbers 313010232 and 81401261).

Supplementary material

10815_2016_793_MOESM1_ESM.pdf (49 kb)
ESM 1 ᅟ(PDF 48 kb)


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.The Reproductive Medicine Hospital of the First Hospital of Lanzhou UniversityLanzhouChina
  2. 2.Department of SurgeryPeople’s HospitalMinqinChina

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