Semen as virus reservoir?
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The recent Ebola outbreak prompted our group to perform a systematic literature search about semen and the Ebola virus. Of interest was the fact that the Ebola virus has been cultured from semen samples collected 2 and 3 months after disease onset, despite that the virus was cleared from the blood of these patients [1, 2, 3]. Based on this information, we advocate the evident need to avoid unprotected sexual intercourse for at least 3 months after clearance of the Ebola virus from the blood .
More recently, NEJM published two interesting papers regarding the Ebola virus and semen. In the first paper, the authors found that semen samples from Ebola virus disease (EVD) survivors remained positive for up to 9 months (272 days) after the onset of symptoms. However, the detection was done by quantitative RT-PCR, thereby indicating the presence of the virus but not whether it is infectious . The second article is based on a case report regarding a 44-year-old woman infected with the...
KeywordsHuman Immunodeficiency Virus Sexual Intercourse Semen Sample Sexual Transmission Vaginal Intercourse
- 4.Cardona-Maya WD, Hernandez PA, Henao DE. Male Ebola survivors: do not forget to use a condom! Reproductive sciences. 2014.Google Scholar
- 5.Deen GF, Knust B, Broutet N, Sesay FR, Formenty P, Ross C, et al. Ebola RNA persistence in semen of Ebola virus disease survivors—preliminary report. The New England journal of medicine. 2015.Google Scholar
- 6.Mate SE, Kugelman JR, Nyenswah TG, Ladner JT, Wiley MR, Cordier-Lassalle T, et al. Molecular evidence of sexual transmission of Ebola virus. The New England journal of medicine. 2015.Google Scholar
- 14.Sánchez JA, Cardona-Maya W, Rugeles MT. Implicaciones de la trasmisión del VIH a partir de espermatozoides humanos durante la fecundación. Rev Cuba Obstet Ginecol. 2013;39(3):249–59.Google Scholar
- 24.McCarthy M. Couples at risk from exposure to Zika virus should consider delaying pregnancy, says CDC. BMJ (Clinical research ed). 2016;352:i1813.Google Scholar