References
Patounakis G, Bergh E, Forman EJ, Tao X, Lonczak A, Franasiak JM, et al. Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients. J Assist Reprod Genet. 2016;33:67–73.
Di Nisio M, Rutjes AW, Ferrante N, Tiboni GM, Cuccurullo F, Porreca E. Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis. Blood. 2011;118:2670–8.
Grandone E, Colaizzo D, Lo Bue A, Checola MG, Cittadini E, Margaglione M. Inherited thrombophilia and in vitro fertilization implantation failure. Fertil Steril. 2001;76:201–2.
Qublan HS, Eid SS, Ababneh HA, Amarin ZO, Smadi AZ, Al-Khafaji FF, et al. Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod. 2006;21:2694–8.
Safdarian L, Najmi Z, Aleyasin A, Aghahosseini M, Rashidi M, Asadollah S. Recurrent IVF failure and hereditary thrombophilia. Iran J Reprod Med. 2014;12:467–70.
Haggarty P, McCallum H, McBain H, Andrews K, Duthie S, McNeill G, et al. Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study. Lancet. 2006;367:1513–9.
Floyd CN, Mustafa A, Ferro A. The PlA1/A2 polymorphism of glycoprotein IIIa as a risk factor for myocardial infarction: a meta-analysis. PLoS One. 2014;9, e101518.
Floyd CN, Ellis BH, Ferro A. The PlA1/A2 polymorphism of glycoprotein IIIa as a risk factor for stroke: a systematic review and meta-analysis. PLoS One. 2014;9, e100239.
Komsa-Penkova R, Golemanov G, Tsankov B, Ivanov P, Beshev L, Tonchev P. Rs5918ITGB3 polymorphism, smoking, and BMI as risk factors for early onset and recurrence of DVT in young women. Clin Appl Thromb Hemost. 2016. doi:10.1177/1076029615624778.
Vlachadis N, Tsamadias V, Kouskouni E, Vitoratos N, Hatziveis K, Economou E. Genetic heterogeneity of platelet glycoproteins Ia and IIIa is associated with in vitro fertilisation implantation failure. J Obstet Gynaecol. 2015;35:733–6.
Ivanov P, Tsvyatkovska T, Konova E, Komsa-Penkova R. Inherited thrombophilia and IVF failure: the impact of coagulation disorders on implantation process. Am J Reprod Immunol. 2012;68:189–98.
Coulam CB, Jeyendran RS, Fishel LA, Roussev R. Multiple thrombophilic gene mutations are risk factors for implantation failure. Reprod Biomed Online. 2006;12:322–7.
Floyd CN, Ferro A. The PlA1/A2 polymorphism of glycoprotein IIIa in relation to efficacy of antiplatelet drugs: a systematic review and meta-analysis. Br J Clin Pharmacol. 2014;77:446–57.
Vlachadis N, Tsamadias V, Economou E. Aspirin to improve IVF unexplained implantation rates: time for an individualized approach. Reprod Biomed Online. 2014;28:133.
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Capsule In contrast to the inconclusive results yielded for most inherited thrombophilic factors, there is accumulating evidence that the PIA2 allele of the platelet glycoprotein IIIa gene is associated with increased risk of IVF implantation failure.
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Vlachadis, N., Vrachnis, N. & Economou, E. The PlA2 variant of the platelet glycoprotein IIIa as a genetic risk factor for IVF implantation failure: accumulating evidence. J Assist Reprod Genet 33, 967–968 (2016). https://doi.org/10.1007/s10815-016-0722-4
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DOI: https://doi.org/10.1007/s10815-016-0722-4