Genetic counseling for men with recurrent pregnancy loss or recurrent implantation failure due to abnormal sperm chromosomal aneuploidy

  • Taylor P. Kohn
  • Jaden R. Kohn
  • Sandra Darilek
  • Ranjith Ramasamy
  • Larry LipshultzEmail author



The purpose of this study is to review recurrent pregnancy loss (RPL) due to sperm chromosomal abnormalities and discuss the genetic counseling that is required for men with sperm chromosomal abnormalities.


The literature was reviewed, and a genetic counselor lends her expertise as to how couples with RPL and sperm chromosomal abnormalities ought to be counseled. The review of the literature was performed using MEDLINE.


Sperm fluorescence in situ hybridization (FISH) can be used to determine if disomy or unbalanced chromosomal translocations are present. In men with aneuploidy in sperm or who carry a chromosomal translocation, pre-implantation genetic screening (PGS) combined with in vitro fertilization (IVF) and intra-cytoplasmic sperm injection (ICSI) can increase chances of live birth. In men with abnormal sperm FISH results, the degree of increased risk of abnormal pregnancy remains unclear. Genetic counselors can provide information to couples about the risk for potential trisomies and sex chromosome aneuploidies and discuss their reproductive and testing options such as PGS, use of donor sperm, and adoption. The provision of genetic counseling also allows a couple to be educated about recommended prenatal testing since pregnancies conceived with a partner who has had abnormal sperm FISH are considered to be at increased risk for aneuploidy.


We review the literature and discuss genetic counseling for couples with RPL or recurrent implantation failure due to increased sperm aneuploidy.


Chromosomal aneuploidy Male infertility Sperm FISH Genetic counseling Recurrent pregnancy loss 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Taylor P. Kohn
    • 1
  • Jaden R. Kohn
    • 1
  • Sandra Darilek
    • 2
  • Ranjith Ramasamy
    • 3
  • Larry Lipshultz
    • 4
    Email author
  1. 1.Baylor College of MedicineHoustonUSA
  2. 2.Molecular and Human Genetics Clinical ProgramBaylor College of MedicineHoustonUSA
  3. 3.Department of Urology, Miller School of MedicineUniversity of MiamiMiamiUSA
  4. 4.Scott Department of UrologyBaylor College of MedicineHoustonUSA

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