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Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway

  • Reproductive Physiology and Disease
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study was to explore the molecular pathway of BSTCR (Bu Shen Tiao Chong recipe) in retrieving diminished ovary reserve (DOR).

Methods

The DOR model was established through injecting cyclophosphamide and the effect of BSTCR was examined under this background.

Results

BSTCR was shown to restore depleted brain-derived neurotrophic factor (BDNF), CDC2, cyclin B, GSH1, and P38 levels as well as impaired oocyte maturation and the higher apoptosis induced in DOR. BSTCR also enhances the response of oocytes to in vitro fertilization, with higher implantation rate, birth rate, and placenta weight.

Conclusion

BSTCR might exert its beneficial role in oocyte maturation and restore DOR through regulating the BDNF pathway. And this pathway itself is probably through the consequence on several serum hormones such as FSH, E2, Inhibin B, etc.

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Abbreviations

IVF:

In vitro fertilization

FSH:

Follicle-stimulating hormone

E2:

Estradiol

AMH:

Anti-Müllerian hormone

INHB:

Inhibin B

BDNF:

Brain-derived neurotrophic factor

BSTCR:

Bu Shen Tiao Chong recipe

DOR:

Diminished ovarian reserve

ICM:

Inner cell mass

TE:

Trophoblast

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (General Program, 81273791).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People’s Republic of China

    Tian Xia, Yu Fu, Shuang Li, Ruihong Ma, Zhimei Zhao, Baojuan Wang & Chune Chao

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  1. Tian Xia
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  2. Yu Fu
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  3. Shuang Li
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  4. Ruihong Ma
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  7. Chune Chao
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Correspondence to Tian Xia.

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Funding

This work is supported by National Science Foundation for Post-doctoral Scientists of China (Grant No. 2014M562161).

Additional information

Capsule BSTCR might exert its beneficial role in oocyte maturation and restore DOR through regulating the BDNF pathway.

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Xia, T., Fu, Y., Li, S. et al. Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway. J Assist Reprod Genet 33, 795–805 (2016). https://doi.org/10.1007/s10815-016-0697-1

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  • DOI: https://doi.org/10.1007/s10815-016-0697-1

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