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Journal of Assisted Reproduction and Genetics

, Volume 32, Issue 9, pp 1421–1427 | Cite as

Association between IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis

  • Young Ho Lee
  • Sung Jae Choi
  • Jong Dae Ji
Genetics

Abstract

Objective

The aim of this study was to determine whether interleukin-6 (IL-6) −174 G/C, IL-6 −634 G/C, and interferon-γ (IFN-γ) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL).

Methods

We conducted a literature search using PubMed and EMBASE databases and performed a meta-analysis using fixed- or random-effects models.

Results

A total of 15 articles met the study inclusion criteria. When all study subjects were considered together, meta-analysis showed no association between RPL and the IL-6 −174 GG + GC genotype (odds ratio [OR] = 0.794, 95 % confidence interval [CI] = 0.542–1.163, p = 0.236). However, stratification of the data by ethnicity indicated an association between this genotype and RPL in non-Caucasians (OR = 0.528, 95 % CI = 0.302–0.925, p = 0.028), but not in Caucasian populations. Moreover, meta-analysis revealed an association between RPL and the IL-6 −634 GG + GC genotype in all study subjects (OR = 0.556, 95 % CI = 0.383–0.806, p = 0.002), while stratification by ethnicity revealed a negative association between this genotype and RPL in Asian (OR = 0.545, 95 % CI = 0.371–0.800, p = 0.002) but not Middle Eastern populations. Furthermore, a relationship between the IFN-γ +874 A allele and RPL was identified in non-Caucasians (OR = 1.403, 95 % CI = 1.133–1.734, p = 0.002), but not in Caucasians.

Conclusions

This meta-analysis demonstrates that IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms are associated with susceptibility to RPL, particularly in non-Caucasians.

Keywords

IL-6 IFN-γ Polymorphism RPL Meta-analysis 

Notes

Acknowledgments

This research received no specific grant from any public, commercial, or not-for-profit sectors funding agency.

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Division of Rheumatology, Department of Internal Medicine, Korea University Anam HospitalKorea University College of MedicineSeoulSouth Korea

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