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Meta-analysis of the association of AhR Arg554Lys, AhRR Pro185Ala, and ARNT Val189Val polymorphisms and endometriosis risk in Asians

  • Genetics
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Abstract

Purpose

Several studies have suggested an association between the polymorphisms AhR Arg554Lys, AhRR Pro185Ala, and ARNT Val189Val and endometriosis, but results have been inconclusive. The aim of the present study was to assess these associations by meta-analysis.

Methods

Eligible literatures were retrieved from PubMed, ISI Web of Science, Elsevier Science Direct, and several Chinese databases. The pooled odds ratios (ORs) and the corresponding 95 % confidence intervals (CIs) were calculated with a random or fixed-effect model.

Results

A total of six eligible studies were included. Regarding the AhR Arg554Lys and ARNT Val189Val polymorphisms, no obvious associations were found in either overall analysis or subgroup analysis based on the country, source of control, sample size, and genotyping method. For the AhRR Pro185Ala polymorphism, overall results suggested a marginal association with endometriosis susceptibility under the dominant model (OR = 1.65, 95 % CI = 1.00–2.72). Furthermore, a significantly increased risk for endometriosis was found in the subgroups which used the TaqMan method for genotype analysis or had a sample size ≥200.

Conclusions

This meta-analysis suggested that the polymorphisms of AhR Arg554Lys and ARNT Val189Val are not associated with endometriosis, while the AhRR Pro185Ala polymorphism may be associated with endometriosis risk. However, further case–control studies with larger sample sizes are needed to confirm our results.

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Acknowledgments

This work was financially supported by the Science and Technology Foundation of Public Welfare Profession of Zhejiang Province (grant no. 2015C33198) and Foundation of Health Bureau of Zhejiang Province (grant no. 2012KYA159).

Competing interests

The authors declare that they have no competing interests.

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Author notes

    Authors and Affiliations

    1. Department of Gynecology and Obstetrics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China

      Neng-neng Zheng & Ying Zheng

    2. Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China

      Ya-ping Bi

    3. Institution of Obstetrics and Gynecology, Zhejiang Medical College, 481 Bin-Wen Road, Bin Jiang District, Hangzhou, Zhejiang, 310053, China

      Ruo-heng Zheng

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    1. Neng-neng Zheng
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    2. Ya-ping Bi
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    Correspondence to Ruo-heng Zheng.

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    Capsule

    This meta-analysis suggested that the polymorphisms of AhR Arg554Lys and ARNT Val189Val are not associated with endometriosis, while the AhRR Pro185Ala polymorphism may be associated with endometriosis risk.

    Neng-neng Zheng and Ya-ping Bi contributed equally to this work.

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    Zheng, Nn., Bi, Yp., Zheng, Y. et al. Meta-analysis of the association of AhR Arg554Lys, AhRR Pro185Ala, and ARNT Val189Val polymorphisms and endometriosis risk in Asians. J Assist Reprod Genet 32, 1135–1144 (2015). https://doi.org/10.1007/s10815-015-0505-3

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    • DOI: https://doi.org/10.1007/s10815-015-0505-3

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