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Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population.

Methods

The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males.

Results

We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility.

Conclusions

There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.

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Acknowledgments

The project is supported by the Wenzhou Science and Technology Bureau Program (Grant number: Y20110124).

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Author notes

    Authors and Affiliations

    1. Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China

      Wuhua Ni, Haiyan Yang, Xu Yang & Xuefeng Huang

    2. Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China

      Aihua Wu, Peili Zhang & Lei Jiang

    3. Huzhou Maternity & Child Health Care Hospital, Huzhou, China

      Haiyan Li

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    1. Wuhua Ni
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    Correspondence to Xuefeng Huang or Lei Jiang.

    Additional information

    Capsule The four SNPs of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, are not associated with male infertility in the Chinese population

    Wuhua Ni and Haiyan Li contributed equally to this work.

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    Ni, W., Li, H., Wu, A. et al. Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population. J Assist Reprod Genet 32, 369–374 (2015). https://doi.org/10.1007/s10815-014-0423-9

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    • DOI: https://doi.org/10.1007/s10815-014-0423-9

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