Journal of Assisted Reproduction and Genetics

, Volume 32, Issue 3, pp 407–408 | Cite as

Is it time to consider patients suffering from endometriosis-related infertility as “novel candidates” for targeted peri-conceptional D-chiro inositol supplementation? Hypothesis, rationale and some considerations

  • Amerigo Vitagliano
  • Marco Noventa
  • Salvatore Gizzo
Letter to the editor

Dear Editor,

We read with great pleasure the interesting data reported by Piomboni et al. concerning several advantages patients affected by polycystic ovarian syndrome (PCOS) and undergoing controlled ovarian hyperstimulation (COH) with pre-treatment supplementation by D-chiro inositol and/or metformin treatment. [1] The demonstrat D-chiro inositol supplementation and metformin treatment were both shown to significantly improve the follicular fluid (FF) milieu by decreasing the oxidative damage (measured as free-SH groups levels) on FF proteins and, as a consequence, significantly increase the number of good quality MII oocytes.

Although for many years it was known that the oxidative stress could have a negative effects on FF environment, recent evidence has suggested that good quality oocytes require a correct balance in FF pro-oxidative and anti-oxidative factors, [2] since an excess in pro-oxidative status is associated with poor quality oocytes, low fertilization and implantation...


Melatonin Endometriosis Follicular Fluid PCOS Patient Metformin Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Amerigo Vitagliano
    • 1
  • Marco Noventa
    • 1
  • Salvatore Gizzo
    • 1
  1. 1.Department of Woman and Child HealthUniversity of PaduaPaduaItaly

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