Is it time to consider patients suffering from endometriosis-related infertility as “novel candidates” for targeted peri-conceptional D-chiro inositol supplementation? Hypothesis, rationale and some considerations
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We read with great pleasure the interesting data reported by Piomboni et al. concerning several advantages patients affected by polycystic ovarian syndrome (PCOS) and undergoing controlled ovarian hyperstimulation (COH) with pre-treatment supplementation by D-chiro inositol and/or metformin treatment.  The demonstrat D-chiro inositol supplementation and metformin treatment were both shown to significantly improve the follicular fluid (FF) milieu by decreasing the oxidative damage (measured as free-SH groups levels) on FF proteins and, as a consequence, significantly increase the number of good quality MII oocytes.
Although for many years it was known that the oxidative stress could have a negative effects on FF environment, recent evidence has suggested that good quality oocytes require a correct balance in FF pro-oxidative and anti-oxidative factors,  since an excess in pro-oxidative status is associated with poor quality oocytes, low fertilization and implantation...
KeywordsMelatonin Endometriosis Follicular Fluid PCOS Patient Metformin Treatment
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