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Journal of Assisted Reproduction and Genetics

, Volume 32, Issue 4, pp 495–508 | Cite as

Clinically relevant known and candidate genes for obesity and their overlap with human infertility and reproduction

  • Merlin G. Butler
  • Austen McGuire
  • Ann M. Manzardo
Review

Abstract

Purpose

Obesity is a growing public health concern now reaching epidemic status worldwide for children and adults due to multiple problems impacting on energy intake and expenditure with influences on human reproduction and infertility. A positive family history and genetic factors are known to play a role in obesity by influencing eating behavior, weight and level of physical activity and also contributing to human reproduction and infertility. Recent advances in genetic technology have led to discoveries of new susceptibility genes for obesity and causation of infertility. The goal of our study was to provide an update of clinically relevant candidate and known genes for obesity and infertility using high resolution chromosome ideograms with gene symbols and tabular form.

Methods

We used computer-based internet websites including PubMed to search for combinations of key words such as obesity, body mass index, infertility, reproduction, azoospermia, endometriosis, diminished ovarian reserve, estrogen along with genetics, gene mutations or variants to identify evidence for development of a master list of recognized obesity genes in humans and those involved with infertility and reproduction. Gene symbols for known and candidate genes for obesity were plotted on high resolution chromosome ideograms at the 850 band level. Both infertility and obesity genes were listed separately in alphabetical order in tabular form and those highlighted when involved with both conditions.

Results

By searching the medical literature and computer generated websites for key words, we found documented evidence for 370 genes playing a role in obesity and 153 genes for human reproduction or infertility. The obesity genes primarily affected common pathways in lipid metabolism, deposition or transport, eating behavior and food selection, physical activity or energy expenditure. Twenty-one of the obesity genes were also associated with human infertility and reproduction. Gene symbols were plotted on high resolution ideograms and their name, precise chromosome band location and description were summarized in tabular form.

Conclusions

Meaningful correlations in the obesity phenotype and associated human infertility and reproduction are represented with the location of genes on chromosome ideograms along with description of the gene and position in tabular form. These high resolution chromosome ideograms and tables will be useful in genetic awareness and counseling, diagnosis and treatment to improve clinical outcomes.

Keywords

Obesity Obesity susceptibility genes Gene symbols Human infertility and reproduction High resolution chromosome ideogram 

Notes

Acknowledgments

We thank Carla Meister for expert preparation of the manuscript, Dr. Syed Rafi for assistance in literature review and Lorie Gavulic for excellent artistic design and preparation of chromosome ideograms.

Funding

Partial funding support was provided by the Prader-Willi Syndrome Association (USA), the Headley Family Scholarship, the National Institute of Child Health and Human Development (NICHD) HD02528 and from the Angelman, Rett and Prader-Willi Syndromes Consortium (U54 HD06122) which is part of the National Institute of Health (NIH) Rare Disease Clinical Research Network (RDCRN) supported through collaboration between the NIH Office of Rare Disease Research (ORDR) at the National Center of Advancing Translational Science (NCATS) and NICHD. The content is solely the responsibility of the authors and does not necessarily represent the office views of the National Institutes of Health.

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Merlin G. Butler
    • 1
  • Austen McGuire
    • 1
  • Ann M. Manzardo
    • 1
  1. 1.Departments of Psychiatry & Behavioral Sciences and PediatricsUniversity of Kansas Medical CenterKansas CityUSA

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